Examples of 'matrix metalloproteinase' in a sentence
Meaning of "matrix metalloproteinase"
matrix metalloproteinase: A group of enzymes that help in breaking down proteins in the extracellular matrix
How to use "matrix metalloproteinase" in a sentence
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matrix metalloproteinase
Role of matrix metalloproteinase in atrial remodeling in heart failure.
Numerous peptides are known matrix metalloproteinase inhibitors.
Matrix metalloproteinase inhibitors are well known in the literature.
It would thus be advantageous to provide additional matrix metalloproteinase inhibitors.
A matrix metalloproteinase inhibitor may be added.
The following assays may be used to identify matrix metalloproteinase inhibitors.
Zymograms to detect matrix metalloproteinase activity were performed as described previously.
This effect was suggested to be partly due to a modulation of matrix metalloproteinase activity.
Matrix metalloproteinase and reprolysin inhibitors are well known in the literature.
Describes certain biphenyl compounds that apparently inhibit matrix metalloproteinase.
Process for preparing matrix metalloproteinase inhibitors and chiral auxiliary therefor.
Peptides homologous to these regions constitute novel matrix metalloproteinase inhibitors.
Tanomastat is one of the matrix metalloproteinase inhibitors that can be used to treat cancer.
The method typically involves contacting fibrinogen or fibrin with a matrix metalloproteinase.
Excessive matrix metalloproteinase and myofibroblast accumulation in the wound margins can result in contracture.
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The potency of inhibitory activity against each matrix metalloproteinase is confirmed as below.
Matrix metalloproteinase enzymes play a major role in extracellular matrix component degradation and remodelling.
Discloses that green tea catechins may have inhibitory effects on matrix metalloproteinase.
Examples of useful matrix metalloproteinase inhibitors are described in PCT Publication No.
The products of the aforesaid reaction can be converted into matrix metalloproteinase inhibitors.
Examples of useful matrix metalloproteinase inhibitors are described in International Patent Publication Nos.
Thiopeptolide substrates show virtually no decomposition or hydrolysis in the absence of a matrix metalloproteinase enzyme.
Therefore, inhibitors to matrix metalloproteinase are useful as antiinflammatory agents.
Pharmaceutical composition containing chalcone or its derivatives for matrix metalloproteinase inhibitory activity.
Matrix metalloproteinase inhibitors for example batimastat, marimastat, prinostat or metastat.
Several representative compounds have been evaluated for their ability to inhibit various matrix metalloproteinase enzymes.
These are the only non-peptide matrix metalloproteinase inhibitors disclosed to date.
In certain embodiments, anti-VEGFR antibodies of the invention are coadministered with matrix metalloproteinase inhibitors.
Natchus et al describe development of new hydroxamate matrix metalloproteinase inhibitors derived from functionalized 4-aminoprolines.
In some embodiments, the functionalized tissue treatment product comprises at least one matrix metalloproteinase.
Therefore, there is an increasing need to develop matrix metalloproteinase inhibitors with a well-defined specificity profile.
In addition, the invention provides diagnostic and therapeutic kits which include a fibrinolytic matrix metalloproteinase.
The method of claim 3, wherein the substrate of matrix metalloproteinase is gelatin or collagen.
MMP1 is a matrix metalloproteinase that is often secreted by senescent cells.
Such side effects have prevented the further development of certain matrix metalloproteinase inhibitor drug candidates.
The most preferred matrix metalloproteinase and TACE inhibiting compounds of this invention are,.
In one embodiment, the cell overexpresses a matrix metalloproteinase.
TGF-B downregulates matrix metalloproteinase expression needed for both angiogenesis and metastasis.
Drugs potentially affecting metastasis of tumours such as matrix metalloproteinase inhibitors ;.
TGF-beta downregulates matrix metalloproteinase expression needed for both angiogenesis and metastasis.
The pharmaceutical agent according to claim 6, which is a matrix metalloproteinase inhibitor.
The matrix metalloproteinase inhibitor and down-regulator according to claim 1 wherein the peptide motif is CTTHWGFTLC.
The compounds of the invention are inhibitors of matrix metalloproteinase enzymes ( MMPs ).
Characterization of - KB and matrix metalloproteinase MMP regulation, and DNA damage caused by oxidative stress.
Drugs potentially affecting metastasis of tumors such as matrix metalloproteinase inhibitors ;.
Preferably, the matrix metalloproteinase is of type 1.
The compound of claim 1, suitable for use as an extracellular matrix metalloproteinase inhibitor.
Telomerase inhibitors for example telomestatin ; Matrix metalloproteinase inhibitors for example batimastat, marimastat, prinostat or metastat.
The most important enzyme of matrix degradation is matrix metalloproteinase ( MMP ).
In a preferred embodiment, the matrix metalloproteinase is stromelysin-1 or gelatinase-A.
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Mass of each version a matrix shall be provided
The matrix of key controls is currently being updated
