Examples of 'maximum tolerated dose' in a sentence
Meaning of "maximum tolerated dose"
The term 'maximum tolerated dose' (MTD) is commonly used in medical and pharmaceutical contexts. It refers to the highest amount of a drug or substance that a patient can tolerate without experiencing unacceptable side effects or toxicity. Determining the MTD is crucial in establishing safe and effective dosages for treatment
How to use "maximum tolerated dose" in a sentence
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maximum tolerated dose
At a dose that is the maximum tolerated dose.
A maximum tolerated dose of telbivudine has not been determined.
Safety profile at maximum tolerated dose.
Maximum tolerated dose studies are also done in clinical trials.
The primary endpoint was to determine the maximum tolerated dose.
The maximum tolerated dose could not be determined.
The effective amount may be at the maximum tolerated dose.
The maximum tolerated dose of ipilimumab has not been determined.
Increases will continue until the maximum tolerated dose is reached.
The maximum tolerated dose of pertuzumab has not been determined.
Toxicity testing is also performed to determine the maximum tolerated dose.
The maximum tolerated dose of etanercept has not been established in humans.
Toxicities are measured at the maximum tolerated dose or the highest dose tested.
Maximum tolerated dose ng.
A series of expansion cohorts is planned when the maximum tolerated dose is determined.
See also
The maximum tolerated dose is typically determined empirically in clinical trials.
The dose of levodopa can be increased as required up to its maximum tolerated dose.
Optimal or maximum tolerated dose level tested in milligrams per kilogram.
These patients can continue in the protocol at their maximum tolerated dose.
It is anticipated that a maximum tolerated dose may not be established in this study.
The chemotherapeutic agent can be administered at less than the maximum tolerated dose.
The maximum tolerated dose can be readily determined by one skilled in the art.
The purpose of the tests was to identify the maximum tolerated dose of inhaled drug.
A maximum tolerated dose of Xolair has not been determined.
These studies will include dose range and maximum tolerated dose studies.
The maximum tolerated dose of Perjeta has not been determined.
Administration may be carried out simultaneously or periodically within the maximum tolerated dose.
A method for determining the maximum tolerated dose for acute in vivo cytogenetic studies.
Maximum tolerated dose studies ( prelude to carcinogenicity studies ) were conducted in rats.
MTD means maximum tolerated dose.
Following dose escalation, enrollment was expanded at the maximum tolerated dose.
Establishing the maximum tolerated dose is the main objective of Phase I clinical trials.
Phase 1 had determined the maximum tolerated dose.
As a result, no maximum tolerated dose was established by the study.
However, the substance has not been tested at the maximum tolerated dose.
Have you done maximum tolerated dose studies?
Maximum tolerated dose and the recommended phase 2 dose have not yet been determined.
Ten new subjects were then enrolled to take the maximum tolerated dose for 3 months.
The maximum tolerated dose was increased by 39 fold compared to bupivacaine hydrochloride.
If severe adverse effects appear, reduce the dose until the maximum tolerated dose is achieved.
Have you done maximum tolerated dose studies? Not yet.
In certain embodiments, the Inhibitor is dosed at the maximum tolerated dose.
The maximum tolerated dose of HUMIRA ( adalimumab ) has not been established in humans.
In one embodiment, the DNA damaging agent is administered at the maximum tolerated dose.
The maximum tolerated dose ( MTD ) is usually defined by reference to the relevant patient subpopulation.
Because of no observed dose limiting toxicities ( DLT ) the maximum tolerated dose was not reached.
Maximum tolerated dose and recommended Phase 2 dose have not been determined at this preliminary phase.
The drug was supplied in the drinking water at the maximum tolerated dose of 2 mg / kg / day.
Maximum Tolerated Dose ( MTD ) is the highest daily dose that does not cause overt toxicity.
As used herein, " therapeutic index " is the maximum tolerated dose divided by the efficacious dose.
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Examples of using Dose
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At doses higher than the recommended dose
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