Examples of 'metabolic activation' in a sentence
Meaning of "metabolic activation"
metabolic activation - This phrase is used in the context of biochemistry or pharmacology to refer to the process by which a chemical compound undergoes conversion or transformation within a living organism, typically to become biologically active or produce a specific effect
How to use "metabolic activation" in a sentence
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metabolic activation
Metabolic activation supports regeneration of the skin.
Mammalian exogenous metabolic activation system.
Metabolic activation is required for PhIP to function as a mutagen.
Clastogens active without metabolic activation.
Mechanism of metabolic activation of chloroform by rat liver microsomes.
Clastogens requiring metabolic activation.
Metabolic activation of haloethanes and tests in vitro for mutagenicity.
Irbesartan does not require metabolic activation for its activity.
A metabolic activation system is not used with primary hepatocyte cultures.
Not require metabolic activation.
Metabolic activation of a carcinogen through the activation of mixed function oxidases.
The study of metabolism and metabolic activation of these compounds.
The metabolic activation is a liver fraction containing enzymes needed in metabolism.
Compounds requiring metabolic activation.
The exogenous metabolic activation system does not entirely mimic in vivo conditions.
See also
Tests are carried out with and without extrinsic metabolic activation.
Details of metabolic activation systems.
The cytotoxicity of a substance may be altered in the presence of metabolic activation systems.
Extrinsic metabolic activation system.
The test was repeated and was negative in the presence and absence of metabolic activation.
Some products require metabolic activation in order to exert their genotoxic effects.
Tests conducted in vitro generally require the use of an exogenous source of metabolic activation.
This metabolic activation system cannot mimic entirely the mammalian in vivo conditions.
Sunitinib was not mutagenic in bacteria using metabolic activation provided by rat liver.
In vitro metabolic activation systems cannot mimic entirely the mammalian in vivo conditions.
If appropriate the tests should be performed without and with mammalian metabolic activation.
Metabolic activation means that a less reactive compound is converted to a more reactive molecule.
Pyrimethamine also showed clastogenic activity in mammalian lymphocytes in the absence of metabolic activation.
The condition of a metabolic activation system may depend upon the class of chemical being tested.
A scientific rationale should be given to justify the choice of an alternative metabolic activation system.
Metabolic activation In in vitro tests generally seemed to weaken the mutagenic effect.
Pyridylbisphosphonates do not bind to bone matrix and they seem to need metabolic activation.
Metabolic Activation condition.
Cell cultures are exposed to the test substance both with and without metabolic activation.
Negative with metabolic activation, negative without metabolic activation.
The following substance is a suitable positive control for the reductive metabolic activation method.
Type and composition of metabolic activation system, including acceptability criteria;.
Either of them is acceptable for conducting experiments both with and without metabolic activation.
As appropriate, extrinsic metabolic activation may be incorporated into this test.
Tobacco carcinogens are in fact precarcinogens that require site specific metabolic activation to induce tumors.
Negative results with metabolic activation need to be confirmed on a case-by-case basis.
The following substances are examples of suitable positive controls for assays with metabolic activation.
Negative results with metabolic activation need to be conformed on a case-by-case basis.
Proliferating cells should be exposed to the test substance both with and without metabolic activation.
Positive controls needing metabolic activation should be used at doses eliciting a moderate response 4.
The mutagenicity tests in eukaryotic systems with and without metabolic activation yield no conclusive results.
Metabolic activation is obtained by adding in the medium S9 mix.
Study parameters that might be modified include the concentration spacing and the metabolic activation conditions.
This is a prodrug that requires metabolic activation for cyp2d6 to exert its pharmacologic action.
Cyclophosphamide monohydrate The following substance is a suitable positive control for the reductive metabolic activation method.
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Push button activation also remains available
It was probably drawn in by the stargate activation at first
Storing several activation files on the server
Examples of using Metabolic
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It could be a sign of metabolic disease or postmortem damage
Metabolic studies normally are not required
Numerous combinations of these metabolic pathways were observed
