Examples of 'methylphosphonate' in a sentence
Meaning of "methylphosphonate"
Methylphosphonate is an adjective used to describe a compound or substance that contains a methyl group and a phosphonate group
How to use "methylphosphonate" in a sentence
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methylphosphonate
All phosphodiester groups are replaced methylphosphonate groups.
Methylphosphonate found on the roof of the.
The underlined bases correspond to methylphosphonate bases.
Dimethyl methylphosphonate is also commercially available.
The diaryl alkylphosphonate may be diphenyl methylphosphonate.
Diisopropyl methylphosphonate is not known to occur naturally in the environment.
Examples of modified phosphate groups are phosphorothioate or methylphosphonate.
Grams of crude diphenyl methylphosphonate was produced.
Methylphosphonate rocket warhead.
In a preferred embodiment the phosphonate group is a methylphosphonate group.
Alternative approaches used methylphosphonate or phosphoramidate linkages in said arms.
Special monomers have to be synthesized in order to prepare methylphosphonate oligonucleotides.
A preferred analogue is a methylphosphonate analogue of the naturally occurring mononucleosides.
In some embodiments the antisense polynucleotides comprise methylphosphonate moieties.
Particularly preferred are the methylphosphonate oligonucleotides and the phosphorothioate oligonucleotides.
See also
Examples of nuclease resistant linkages are phosphothioate and methylphosphonate linkages.
Phosphorothioate and methylphosphonate antisense oligonucleotides are specifically contemplated for therapeutic use.
The other synthesizer was used for introduction of methylphosphonate portions.
Phosphorothioate and methylphosphonate linkages confer added stability to the oligomer in physiological environments.
A preferred alkylphosphonate is a methylphosphonate.
Phosphorothioate and methylphosphonate antisense oligonucleotides are specifically contemplated for therapeutic use by the invention.
The RNAi agent may further comprise at least one phosphorothioate or methylphosphonate internucleotide linkage.
In addition, methylphosphonate linkages were placed at the ends of the molecule.
A synthesis and purification scheme for a racemic methylphosphonate neutral probe is described in this example.
In certain embodiments, the diaryl alkylphosphonate may be diphenyl methylphosphonate.
The diethyl methylphosphonate is distilled under nitrogen, under reduced pressure.
This approach is useful for the stereocontrolled synthesis of phosphorothioate and methylphosphonate oligonucleotide analogues.
Methylphosphonate linkages can be easily introduced into DNA fragments using standard ( phosphoramidite ) DNA chemistry.
Methylphosphonic acid Diethyl methylphosphonate.
Methylphosphonate rocket warhead . Isopropyl methyl Hexamethylentetramine.
Most preferably, the alkylphosphonate CpG is a methylphosphonate CpG.
In addition, methylphosphonate linkages were placed at the ends of the molecule ( indicated as MeP ).
Examples are phosphorothioate, phosphorodithioate, phosphoramidate and methylphosphonate oligonucleotides.
IPMPA, Isopropyl methylphosphonate ( primary degradation product of GB ).
Examples are phosphorthioate, phosphordithioate, phosphoramidate and methylphosphonate oligonucleotides.
DIMP, Diisopropyl methylphosphonate thermal decomposition / synthesis by-product of GB.
The composition of claim 1 where the oligonucleotide is a methylphosphonate oligonucleotide.
Dimethyl methylphosphonate Methylphosphonyl difluoride ( DF ).
Examples include phosphorthioate, phosphordithioate, phosphoramidate and methylphosphonate oligonucleotides.
Addition of dimethyl methylphosphonate lithium to 11 afford 12.
The method of claim 5 wherein said cutting attenuation modification is methylphosphonate modification.
The single methylphosphonate linkage, 3 ' to the adenosine, as shown in Fig.
In MPnS, this glutamine molecule binds to iron, a necessary cofactor for the production of methylphosphonate.
DMMP is the flame retardant dimethyl methylphosphonate available from Albright & Wilson Ltd.
DIMP Diispropyl taken from the rocket body . dimethylpyrophosphonate Ethyl isopropyl methylphosphonate.
Preferred members of this group are dimethyl methylphosphonate ( DMMP ) and diethyl ethylphosphonate ( DEEP ).
If desired, the RNA molecule can contain phosphoramidate, phosphorothioate, and / or methylphosphonate linkages.
Preferred members of this group are dimethyl methylphosphonate ( DMMP ) and diethyl ethyl phosphonate ( DEEP ).
Other useful additives include fire-retardants, for example, tris-2-chloroethyl phosphate and dimethyl methylphosphonate.
Reaction Set B compared a methylthiophosphonate ( Reaction 6 ) and a methylphosphonate ( Reaction 5 ) to the natural phosphate ( Reaction 4 ).
