Examples of 'mevalonate' in a sentence
Meaning of "mevalonate"
Mevalonate is an adjective related to chemistry or biochemistry. It is used to describe a compound involved in the biosynthesis of important molecules like cholesterol
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- Any salt or ester of mevalonic acid
How to use "mevalonate" in a sentence
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mevalonate
Mevalonate was detected using a refractive index detector.
This inhibition is raised by the presence of mevalonate.
The presence of mevalonate allows the inhibition to be totally raised.
Identification of novel functional inhibitors of the synthesis of mevalonate.
Phenylacetate inhibits the mevalonate pathway and protein isoprenylation.
Monoterpenes have multiple pharmacological effects on the metabolism of mevalonate.
A diphosphomevalonate decarboxylase is able to catalyze the decarboxylation of mevalonate diphosphate.
Plates were incubated at room temperature overnight to allow lactonization of mevalonate to mevalonolactone.
Mevalonate kinases are found in a wide variety of organisms from bacteria to mammals.
We then examined the function of mevalonate modification in this particle formation.
Mevalonate pyrophosphate decarboxylase.
Statin drugs might decrease the level of mevalonate and are presently being investigated.
Mevalonate kinase deficiency.
It is preferred that a modified mevalonate kinase of the invention is administered as a therapeutic enzyme.
Mevalonate is the precursor for formation of steroids and the isoprenoids of steroids.
See also
Secologanin is a secoiridoid monoterpene synthesized from geranyl pyrophosphate in the mevalonate pathway.
The modified mevalonate kinase of the invention may be an isolated polypeptide.
Constructs for the remaining genes of the mevalonate pathway have been designed.
The mevalonate pathway is responsible for the biosynthesis of isoprenoids from acetate.
Cells were plated and maintained in lovastatin and mevalonate throughout the experiment.
The presence of mevalonate gives the possibility of totally lifting the inhibition of growth.
That these mutations have an impact on feedback inhibition of mevalonate kinase is surprising.
These mevalonate derivatives are the naturally occurring fungal metabolites lovastatin and compactin.
Mevalonic acid is a key intermediate in the mevalonate pathway responsible for synthesis of cholesterol.
Mevalonate will pass across the cellular membrane and accumulate in the media.
The polynucleotide must encode at least one of the enzymes in the mevalonate pathway.
The present invention provides modified mevalonate kinases that are less sensitive to feedback inhibition.
The vast majority of terpenes are derived from the enzymatically catalyzed mevalonate pathway.
The increased yield of mevalonate production by these strains is therefore advantageous for commercial applications.
They lower cholesterol production in the liver by inhibiting an factor in the mevalonate pathway.
Method for selecting mevalonate synthesis modulators using cells derived from human pluripotent cells.
Several of the fragments contained sequences homologous to genes encoding proteins of the mevalonate pathway.
Overexpression of the genes of the mevalonate pathway in Paracoccus sp.
These mevalonate pathway nucleic acids were cloned from Sacchromyces cerevisiae.
In Genbank this enzyme is classified as a mevalonate diphosphate decarboxylase.
The mechanism of action is to regulate the speed of change of HMG to mevalonate.
The arrangement of the mevalonate pathway genes in the Paracoccus sp.
HMG CoA synthase is part of the mevalonate pathway.
Therefore, three mevalonate producing strains were compared.
A multiple amino acid sequence alignment of different mevalonate kinases see Fig.
As phosphate donors for mevalonate kinase, different compounds are conceivable.
Numbering is according to the amino acid sequence of Paracoccus zeaxanthinifaciens mevalonate kinase.
The coding regions of the mevalonate operon genes from Paracoccus sp.
No similar studies have been reported for bacteria that produce IPP vía the mevalonate pathway.
Positive clones containing the correct mevalonate operon gene insert were verified by PCR.
The product of HMG CoA reductase is mevalonate.
Construction of mevalonate expression plasmid,.
Staal et al . reported that statins act by inhibiting the mevalonate pathway.
Cholesterol is bio-synthesised from mevalonate via a squalene cyclisation of terpenoids.
Statins inhibit HMG-CoA reductase within the mevalonate pathway.
