Examples of 'minor groove' in a sentence
Meaning of "minor groove"
minor groove - In biology, it refers to the smaller of the two grooves in the DNA double helix structure. It plays a crucial role in regulating gene expression and protein synthesis
How to use "minor groove" in a sentence
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minor groove
As such it is an example of a minor groove triple.
Minor groove binders are described in more detail elsewhere herein.
See supra for disclosure of minor groove binders useful in the oligomers of the invention.
The double helix structure of DNA contains a major groove and minor groove.
A variety of suitable minor groove binders have been described in the literature.
These compounds recognize and bind the minor groove of duplex DNA.
Certain minor groove binders exhibit a preference for particular sequence compositions.
The cytotoxic agent can be a DNA minor groove binding agent.
It binds the minor groove of DNA and cleaves the phosphodiester backbone.
DAPI interacts with double stranded DNA by associating with AT clusters in the minor groove.
An example of a DNA minor groove binder is plicamycin.
A minor groove binder oligonucleotide probe having the formula,.
In one embodiment, the minor groove binder is a modified nucleoside.
In other embodiments, the tail comprises a minor groove binder.
Further preferred minor groove binders are those selected from the formulae,.
See also
Partial intercalation of aliphatic and aromatic residues in helix 2 occurs in the minor groove.
Wherein the minor groove binder oligonucleotide probe has the formula,.
In some embodiments of the present invention, a polynucleotide oligomer comprises a minor groove binder.
A DNA minor groove binder is plicamycin, for example.
The probes / conjugates will also optionally have a covalently attached minor groove binder.
In various embodiments, Xa is a minor groove binder or an intercalating agent.
The above-mentioned compositions can optionally comprise a fluorescence quencher and / or a minor groove binder.
The FRET probe contains a minor groove binder, fluorophore and quencher.
The probes / conjugates of the present disclosure can also have a covalently attached minor groove binder.
For example, in some embodiments, the minor groove binding agent is a CBI compound.
The minor groove binder was the pyrroloindole tripeptide shown in this application in Table 5.
In specific embodiments, the cytotoxic agent is a DNA minor groove binding agent.
Trabectedin binds to the minor groove of DNA, bending the helix to the major groove.
Hoechst is a bis-benzimidazole derivative compound that binds to the minor groove of DNA.
For example, in certain embodiments, the minor groove binding agent is a CBI compound.
Compound C 's strucutre may also mean it binds more strongly in the minor groove.
Chen teaches a minor groove binder ( MGB ) and oligonucleotides having a MGB group.
The histone fold interacts chemically and physically with the DNA 's minor groove.
A preferred drug moiety D is a DNA minor groove binder / alkylator.
In contrast, the minor groove is normally ( with a few exceptions ) relatively unoccupied.
In this example, modified oligonucleotides were prepared containing PPPA, PPG and a minor groove binder.
PBDs include a number of minor groove binders such as anthramycin, neothramycin and DC-81.
The ethidium bromide is a DNA inter-chelator, Hoescht Dye is a minor groove binder.
Minor groove binders include, but are not limited to, compounds such as dihydrocyclopyrroloindole tripeptide ( DPI3 ).
As with monomeric PBDs, the dimers are DNA minor groove binder-alkylators.
Generally, minor groove-binders are dyes that bind to the minor groove of double-stranded DNA.
Thus, the polyamide compound can bind to the minor groove of B-form DNA.
Detail showing the DNA minor groove and the FR60 medication perfectly stacked.
The antibody of claim 9 or 10, wherein the cytotoxic agent is a DNA minor groove binder.
In other embodiments, the minor groove binding agent is an enediyne ( e.g., calicheamicin ).
Is a suitable minor groove binding agent selected from the following groups, t-butoxy, benzyloxy and 9-fluorenylmethyloxy ;.
In other embodiments, the minor groove binding agent is an enediyne ( e . g ., calicheamicin ).
The strong minor groove binding of H33258 may also provide a mechanism for direct isolation of dsDNA.
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