Examples of 'modified backbone' in a sentence
Meaning of "modified backbone"
modified backbone: this phrase could refer to an altered or reinforced support structure, either in a literal or metaphorical sense
How to use "modified backbone" in a sentence
Basic
Advanced
modified backbone
A modified backbone is typically preferred to increase nuclease resistance.
Preferred stabilized nucleic acids have a modified backbone.
One type of modified backbone is a phosphate backbone modification.
A preferred stabilized oligonucleotide has a phosphorothioate modified backbone.
In some embodiments the modified backbone is a phosphate backbone modification.
The polynucleotide may comprise modified bases or a modified backbone.
In other embodiments the modified backbone is a peptide modified oligonucleotide backbone.
The polynucleotide optionally comprises modified bases or a modified backbone.
In more preferred embodiments the modified backbone is a phosphate modified backbone.
Preferred stabilized oligonucleotides of the instant invention have a modified backbone.
In certain preferred embodiments the the modified backbone is a phosphate modified backbone.
The oligonucleotides may be modified DNAs comprising a phosphorothioated modified backbone.
Methods of preparing modified backbone and mixed backbone oligonucleotides are known in the art.
The immunostimulatory oligonucleotides of the instant invention have a modified backbone.
Phosphorodiamidate morpholino oligomers are modified backbone oligonucleotides that have previously been investigated as antisense agents.
See also
A chimeric backbone includes a combination of phosphodiester and modified backbone linkages.
A nucleic acid can comprise a modified backbone and / or modified internucleoside linkages.
Some stabilized oligonucleotides of the instant invention have a modified backbone.
A nucleic acid-targeting nucleic acid can comprise a modified backbone and / or modified internucleoside linkages.
Preferred stabilized nucleic acids of the instant invention have a modified backbone.
The antisense oligonucleotide of claim 3, wherein the modified backbone comprises morpholinos.
A preferred stabilized nucleic acid has at least a partial phosphorothioate modified backbone.
In some embodiments the immunostimulatory oligonucleotides have a modified backbone such as a phosphorothioate ( PS ) backbone.
Immunostimulatory oligonucleotides of the invention comprise at least one phosphorothioate modified backbone.
In one embodiment, the oligonucleotide primer has a modified backbone of Structure I, wherein,.
Preferred stabilized nucleic acid molecules of the instant invention have a modified backbone.
Also according to preferred embodiments the immunostimulatory nucleic acid has a modified backbone.
One type of stabilized nucleic acid has at least a partial phosphorothioate modified backbone.
In one embodiment, the antisense oligonucleotide comprises a modified backbone.
In a preferred embodiment, a nucleotide analogue or equivalent comprises a modified backbone.
An oligonucleotide equivalent according to claim 4, wherein the oligonucleotide comprises a modified backbone.
In a third embodiment, the oligonucleotides are modified DNAs comprising a phosphorothioated modified backbone.
The antisense oligonucleotide of claim 1, wherein said modification comprises a modified backbone.
An antisense oligonucleotide according to claim 5, wherein the nucleotide analogue has a modified backbone.
The oligonucleotide as claimed in any preceding claim, wherein said oligonucleotide has a modified backbone.
The oligonucleotide according to claim 1, which has a modified backbone.
An oligonucleotide according to claim 1 or 3, wherein the oligonucleotide comprises a modified backbone.
The nucleobase oligomer ( or a portion thereof ) may contain a modified backbone.
You'll also be interested in:
Examples of using Modified
Show more
A modified sine wave is generated by this conversion
This warranty may be modified only by RedMax
This modified virus seems to really work
Examples of using Backbone
Show more
Just grow a backbone and call her
Backbone lends support but does not involve
Public administration is the backbone of effective government
