Examples of 'monophosphoryl lipid' in a sentence
Meaning of "monophosphoryl lipid"
monophosphoryl lipid: This phrase likely refers to a type of lipid molecule that contains a single phosphate group. It may have significance in scientific research, pharmaceuticals, or biotechnology, particularly in relation to immune responses or vaccine development
How to use "monophosphoryl lipid" in a sentence
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monophosphoryl lipid
In one aspect the composition is adjuvanted with a monophosphoryl lipid A or derivative thereof.
Monophosphoryl lipid A is a bacterially derived compound with adjuvant activity.
Ribi also contains refined mycobacterial products which act as immunostimulants and bacterial monophosphoryl lipid A.
The aqueous colloidal suspension of monophosphoryl lipid A, sucrose and triethanolamine prepared in ( a ) above is lyophilized.
Again, no mention of the particle size of the 3 deacylated monophosphoryl lipid A was made.
Monophosphoryl lipid A and 3DMLA also protect D-galactosamine loaded mice from a potentially lethal endotoxin challenge.
The name indicates that position 3 of the reducing end glucosamine in monophosphoryl lipid A is de-acylated.
Monophosphoryl lipid A, a strong immunmodulator, was added at a concentration of 40 mg per mmol of phospholipids.
The composition of claim 1, wherein said adjuvant is said monophosphoryl lipid A.
Safety evaluation of monophosphoryl lipid A ( MPL ), an immunostimulatory adjuvant.
The pharmaceutical composition of claim 8, wherein the adjuvant is monophosphoryl Lipid A.
Examples of adjuvants include Freund 's complete and monophosphoryl Lipid A synthetic-trehalose dicorynomycolate ( MPL-TDM ).
A pharmaceutical composition comprising tyrosine, an optionally modified allergen, and 3 de-O-acylated monophosphoryl lipid A.
Chemically it is a mixture of 3-deacylated monophosphoryl lipid A with 4, 5 or 6 acylated chains.
The use of any of claims 1 to 5, wherein the refined detoxified endotoxin is monophosphoryl lipid A.
See also
Preferred adjuvants include monophosphoryl lipid A ( MPL ), and saponins such as Quil-A.
Other suitable adjuvants include alum, biodegradable microspheres, monophosphoryl lipid A and quil A.
Monophosphoryl lipid A ( MPLA ) - loaded nanoparticles are synthesized as described in Example 14.
A vaccine as claimed in claim 14 additionally comprising 3-Deacylated monophosphoryl lipid A.
Further possibilities are monophosphoryl lipid A ( MPL ), and muramyl dipeptide ( MDP ).
The composition of claim 1 or 2, wherein said attenuated lipid A derivative is monophosphoryl lipid A.
The medicaments comprises an effective amount of monophosphoryl lipid A ( MLA ) or 3-deacylated monophosphoryl lipid A ( 3D-MLA ).
Accordingly, the present invention provides a composition comprising 3 Deacylated monophosphoryl lipid A and QS21.
It consists of aluminum hydroxide and monophosphoryl lipid A ( MPL ).
There are also synthetic analogs of LPS that activate TLR4, such as monophosphoryl lipid A [ MPL ].
One example of such a substance is called monophosphoryl Lipid A ( MPL ).
Conventional adjuvants may be used, but a preferred immunostimulant is 3-deacylated monophosphoryl lipid A ( 3D-MPL ).
A preferred “ small particle ” form of 3 De-O-acylated monophosphoryl lipid A is disclosed in ref.
Another useful aluminium-based adjuvant is AS04, a combination of aluminium hydroxide + monophosphoryl lipid A ( MPL ).
Examples of adjuvants include, without limitation, CpG oligonucleotides, monophosphoryl lipid A, and Montanide ISA-51.
A further useful aluminium-based adjuvant is AS04, a combination of aluminium hydroxide and monophosphoryl lipid A ( MPL ).
Preferably the compositions of the invention contain MPL ( 3-deacylated monophosphoryl lipid A, also known as 3D-MPL ).
The method of claim 6, wherein said toll-like receptor agonist is monophosphoryl lipid A ( MPL ).
Hepatitis vaccins containing 3-0 deacylated monophosphoryl lipid A.
In a preferred embodiment this immunostimulant will be 3 Deacylated monophosphoryl lipid A ( 3D-MPL ).
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