Examples of 'myofibroblast' in a sentence
Meaning of "myofibroblast"
myofibroblast (noun) - A myofibroblast is a type of cell involved in wound healing and tissue repair, characterized by both fibroblast and smooth muscle cell properties. It is commonly used in the context of medical research, pathology, or discussions related to cellular biology and regenerative medicine
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- A cell that is intermediate between a fibroblast and smooth muscle
How to use "myofibroblast" in a sentence
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myofibroblast
Cancer exosomes trigger fibroblast to myofibroblast differentiation.
Promotion of myofibroblast apoptosis is a potential therapeutic strategy for pulmonary fibrosis.
Susceptibility to arrhythmia in the infarcted heart depends on myofibroblast density.
The protein marker for myofibroblast différentiation used is αSMA.
A myofibroblast is a cell that is in between a fibroblast and a smooth muscle cell in phenotype.
We found differences among these groups in specialized epithelial and myofibroblast cell populations.
Cells were analyzed for myofibroblast morphology by staining for smooth muscle actin.
Pericytes and renal mesangial cells are some examples of modified myofibroblast like cells.
Myofibroblast proliferation and heterogeneity are supported by macrophages during skin repair.
It can be concluded that the myofibroblast phenotye depends on tension in the surrounding matrix.
Myofibroblast collagen gene expression is a hallmark of remodeling and necessary for scar formation.
Pharmaceutical agents have been investigated which may be able to turn off myofibroblast differentiation.
The myofibroblast is the cell considered to be responsible for the development of desmoid tumor.
Excessive matrix metalloproteinase and myofibroblast accumulation in the wound margins can result in contracture.
This in turn suggests that future therapeutic strategies targeting the myofibroblast would be productive.
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Inhibition of cardiac myofibroblast formation and collagen synthesis by activation and overexpression of adenylyl cyclase.
Hepatic stellate cells are intralobular connective tissue cells expressing the myofibroblast or the lipocyte phenotypes.
Excessive myofibroblast activity also produces the tissue deformations that are characteristic of fibrotic diseases.
We went on to identify which mediators present in SSC are implicated in myofibroblast differentiation.
Myofibroblasts facilitate granulation tissue remodeling vía myofibroblast contraction and through the production of ECM components.
These results indicated that ASE indeed could prevent myofibroblast differentiation of AMSCs.
Recent developments in myofibroblast biology, paradigms for connective tissue remodeling.
At first, contraction occurs without myofibroblast involvement.
The ( proto ) myofibroblast provides for increased tension in skin as compared to a fibroblast.
In normal tissue repair, the myofibroblast disappears.
Around the implant, myofibroblast deposit collagen fibers around the foreign material and eventually contract it.
Indeed, the increased motion following initial surgery may facilitate myofibroblast differentiation and persistence.
Perhaps the most studied pathway of myofibroblast formation is TGF-beta1 dependent differentiation from fibroblast cells.
Stellate cells are known as storage cells for vitamin A, and belong to the myofibroblast family.
However, in fibrotic disease the myofibroblast remains at the injured tissue.
A significant finding of the present study was that PS2 treatment attenuated the BL-induced myofibroblast proliferation.
During the fibrosis process, the fibroblasts have a myofibroblast phenotype and are organised into fibroblastic foci.
Background fluorescence from a no-enzyme control reaction had been subtracted from each value . Myofibroblast culture.
LG3 did not induce myofibroblast differentiation.
In some instances, inhibiting may include delaying ( or slowing the kinetics of ) myofibroblast development.
Figure 3 describes Itraconazole inhibiting Myofibroblast differentiation in multiple cell types in vitro.
The preferred myofibroblast activity down-regulator and / or myofibroblast production ( or differentiation ) inhibitor is TNF-a antagonist.
We next assessed the effect of anti-TNF-a on myofibroblast morphology.
An image of a myofibroblast stained by anti-alpha-actin antibody is seen in Figure 4.
Fig . 22 is a non-limiting example of rapid myofibroblast differentiation of AMSCs in vitro.
FIG . 4 shows myofibroblast labeling 1 week after surgery using alpha smooth muscle actin antibodies.
In addition, knocking down MK5 decreased myofibroblast contraction.
Figure 4 shows myofibroblast labeling ( anti-alpha smooth muscle actin ) at 1 week post-laser surgery.
A-SMA is a well-known marker of myofibroblast.
LT3000 decreases macrophage and myofibroblast density in lung tissue following bleomycin injury.
Over 100 Dupuytren 's patient samples were collected to examine myofibroblast distribution.
LT3000 treatment also decreased myofibroblast density, in the lungs of bleomycin-instilled mice.
FIG . 3 is a graph showing the effect of selective plasma surface activation on myofibroblast differentiation ;.
In addition to promoting myofibroblast differentiation, transforming growth factor-B1 ( TGF-B1 ) provides protection against apoptosis.
TGF-B1 leads to the development of the myofibroblast phenotype.
