Examples of 'neublastin' in a sentence
Meaning of "neublastin"
Neublastin (adjective): a term related to neuroscience and biology referring to a protein involved in neural regeneration and repair
How to use "neublastin" in a sentence
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neublastin
Cells hosting a neublastin vector may be prokaryotic.
Ternary complex assay for neublastin.
The neublastin polypeptide may be expressed in a cell.
Also herein described is a neublastin polypeptide expressed in a cell.
The neublastin may be conjugated to a naturally occurring moiety.
Polymer conjugates of mutated neublastin.
Three mature forms of neublastin polypeptides were identified.
Neublastin can optionally replace or augment a previously or currently administered therapy.
One or more sites on a neublastin polypeptide can be coupled to a polymer.
Neublastin polypeptides can be isolated using methods known in the art.
The signal peptide and the neublastin polypeptide are as described above.
Neublastin polypeptides can be modified using conventional methods and materials.
Residual levels of unmodified neublastin in the product were below the limits of quantitation.
Neublastin can also be used for treating peripheral neuropathy in a mammal.
These novel forms include variant neublastin polypeptides conjugated to polymeric molecules.
See also
The neublastin polypeptide can be recovered from a cell suspension if desired.
This rapid clearance can frustrate the use of neublastin in therapeutic applications.
The variant neublastin polypeptide can be provided as a multimeric polypeptide.
Advantageous sites of modification are those at solvent accessible regions in the neublastin polypeptide.
The cDNA encoding neublastin was originally identified as follows.
Other dimers may include two different variant neublastin polypeptide forms.
The neublastin may be glycosylated.
The vector can be used to express the encoded truncated neublastin polypeptide.
The neublastin polypeptide secreted according to the invention can vary in length.
The invention further concerns mammalian cells capable of producing neublastin in increased amounts.
Neublastin expression was also detected in the olfactory bulb and in the hippocampus.
A fusión protein comprising a neublastin polypeptide operably linked to a human serum albumin protein.
Neublastin fusión proteins also have enhanced pharmacokinetic and bioavailability properties in vivo.
Polypeptides of the present invention also include truncated forms of the neublastin polypeptide.
A neublastin polypeptide that is expressed in a cell may be recovered and conjugated to a polymer.
Also provided by the invention are multimeric polypeptides that include a variant neublastin polypeptide.
This suggests that neublastin may be produced as a glycosylated protein in mammalian cells.
The polyalkylene glycol moiety may be coupled to a cysteine group of the mutated neublastin polypeptide.
Neublastin peptides for use in increasing vascularisation in tissue with impaired blood flow.
The invention further includes the variant neublastin polypeptide produced by the cell.
The neublastin polypeptide in the foregoing uses can also be administered vía intrathecal delivery.
The polymer can be coupled to the neublastin polypeptide using methods known in the art.
Neublastin fusión proteins can have enhanced pharmacokinetic and bioavailability properties in vivo.
Some embodiments of the invention involve neublastin polypeptides containing conservative amino acid substitutions.
In one embodiment use is contemplated of a nerve guidance channel with a matrix containing neublastin polypeptides.
Mutated neublastin polypeptides can be constructed using any of several methods known in the art.
The disclosure provides a method for making a polymer conjugated glycosylated neublastin polypeptide dimer.
This invention features a use of a neublastin polypeptide for use in treating tactile allodynia in a subject.
Polypeptides of the present invention also include truncated forms of the full length neublastin molecule.
Variant neublastin polypeptides can be constructed using any of several methods known in the art.
It is understood that the truncated forms of Neublastin disclosed herein e.
Preferably the neublastin polypeptide is one of the mature forms of the wild type protein.
This sequence was also used to screen GenBank for neublastin EST sequences.
The treatment with neublastin under such circumstances would serve to alleviate said neuropathic pain.
Generation of CHO cell lines expressing Neublastin.
