Examples of 'neurokinin' in a sentence
Meaning of "neurokinin"
Neurokinin (noun): Refers to a type of neuropeptide involved in the regulation of various physiological processes in the nervous system. It is often discussed in the context of neuroscience and pharmacology research
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- A class of tachykinin oligopeptide of the mammalian central nervous system.
How to use "neurokinin" in a sentence
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neurokinin
Vasopressin and neurokinin may also participate.
Tachykinins are peptide ligands for neurokinin receptors.
The role of neurokinin receptors in mediating neuroinflammation has been established.
This publication makes no reference to neurokinin antagonist activity.
The role of neurokinin receptors in mediating neuroinflarnmation has been established.
The potential effects on reproduction of alterations in neurokinin regulation are unknown.
Other neurokinin subtypes and neurokinin receptors that interact with SP have been reported as well.
None of the compounds in the foregoing references are alleged to be neurokinin antagonists.
Neurokinin A produces contraction of airway smooth muscle and increases airway responsiveness to other bronchoconstrictive stimuli.
The present invention relates to a genus of compounds useful as antagonists of neurokinin receptors.
Also included are variants of neurokinin B precursor gene products.
One object of the present invention is to provide new and useful antagonists of neurokinin A.
Novel neurokinin 1 receptor antagonist compounds.
An object of the present invention was to provide novel neurokinin antagonists useful in therapy.
The neurokinin receptor is the poster child for failures in drug discovery to treat pain, ".
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Novel substituted heterocyclic compounds have now been found which are neurokinin receptor antagonists.
Central neurokinin NK1 receptors play a major role in the regulation of emesis.
Eledoisin is a peptide of batrachian origin which is equivalent to neurokinin B.
The polypeptides used include human neurokinin B or its precursor, or variants or fragments thereof.
This invention relates to cyclic peptide derivatives which are antagonists of neurokinin A.
It said a study has found that the hormone, neurokinin B, causes the hormonal surge in adolescence.
The concentration may be assessed by using an antibody specific for neurokinin B.
Neurokinin A possesses the following amino acid sequence,.
Applicants have now discovered a class of neurokinin A antagonists.
A composition for antagonizing neurokinin A receptor comprises a compound as claimed in claim 1.
The invention relates to linear and cyclic synthetic peptides which antagonize neurokinin A.
A composition for antagonizing neurokinin A receptor comprising a compound as claimed in claim 1.
These products have no activity towards neurokinin A.
Neurokinin A ( formally known as substance K ) is a member of the tachykinin family of neuropeptide neurotransmitters.
An epitopic variant or epitopic fragment of human neurokinin B precursor may be used.
Preferably, the neurokinin B precursor polypeptides have the sequences shown in Figure 1.
In another embodiment the level of Substance P or neurokinin is determined.
Synthetic peptide antagonists of neurokinin A, salts thereof and respective preparation processes.
Description of Related Art Tachykinins are peptide ligands for neurokinin receptors.
Preferably the neurokinin B peptide derived from the precursor has the sequence of Figure 2.
In particular, the compounds disclosed herein are neurokinin receptor antagonists.
More recently, neurokinin receptors have been suggested as targets for CNS diseases Albert, Expert Opin.
Use of a compound according to claim 1 in the manufacture of a medicament for inducing neurokinin antagonism.
The effects of neurokinin A are mainly mediated by NK2 receptors.
SP receptors belong to a family of receptors called the neurokinin 1 receptors.
Neurokinin A activates the specific neurokinin receptor referred to as NK2.
As mentioned earlier, the compounds of formula II are antagonists of the neurokinin receptor.
Substance P activates the neurokinin receptor subtype referred to as NK1.
Furthermore, the compounds of the present invention are also active as neurokinin NK 1 antagonists.
The effects of neurokinin A are mainly mediated via the NK2 receptors.
A method according to claim 15 comprising assessing the concentration in a biological sample of neurokinin B.
The compounds of this family include neurokinin B, neurokinin a and substance P.
The use of a compound of Claim 1 or 2 for preparing a medicament useful for inducing neurokinin antagonism.
Neurokinin A, formerly known as Substance K, is a neurologically active peptide translated from the pre-protachykinin gene.
Figure 7 shows the cardiovascular effect of neurokinin B in conscious rats.
