Examples of 'neurotrophin' in a sentence
Meaning of "neurotrophin"
neurotrophin (adjective): relating to a family of proteins that help in the growth, development, and function of neurons in the nervous system
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- Any of a group of proteins that stimulate the growth of nerve cells
How to use "neurotrophin" in a sentence
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neurotrophin
Neurotrophin is a protein that is present in our brain.
Phosphorylation of trks is an immediate response to neurotrophin binding.
Agonists of neurotrophin receptors and their use as medicaments.
One family of neurotrophic factors is the neurotrophin family.
Neurotrophin to be used for therapeutic administration must be sterile.
A therapeutically effective dose of an neurotrophin formulation is administered to a patient.
Neurotrophin compositions are preferably sterile.
Antibodies that recognize and bind fragments of a neurotrophin are also contemplated.
That new neurotrophin might give you more time.
The labels may be incorporated into the pantropic neurotrophin at any position.
Brain TrkB neurotrophin receptor as a target for antidepressant treatments.
As a result of the process described herein the neurotrophin is essentially free of these variants.
Neurotrophin can be delivered to the brain under positive pressure to treat stroke.
The effect of several members of the neurotrophin growth factor family was examined.
The neurotrophin thereafter is solubilized and then subsequently refolded using an appropriate buffer.
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Mechanisms of radioresistance might also be dependent of the transfer of neurotrophin receptors through exosomes.
This has been linked to neurotrophin signalling through primary hippocampal and cortical neurons.
The relative hydrophobicity of correctly folded and misfolded neurotrophin also depended on solution pH.
The process for purifying a neurotrophin may result in considerable improvement in its homogeneity.
The degree of purification necessary will vary depending on the use of the pantropic neurotrophin.
Preferred sequences do not hybridize other known neurotrophin receptor sequences under similar conditions.
Interaction of a neurotrophin ligand with trks induces phosphorylation of specific tyrosine residues on the receptor.
New disease conditions are identified that are associated with this molecule and its neurotrophin ligand.
The recombinant neurotrophin gene may be expressed and purified utilizing any number of methods.
The formulations of the invention include the pantropic neurotrophin pantropic NGF.
Other domains within each neurotrophin may be found using the techniques disclosed herein.
It is possible that the factor involved is CNTF or a member of the neurotrophin family.
DISCLOSURE This invention seeks to provide a neurotrophin receptor agonist or antagonist pharmaceutical composition.
NGF was the first growth factor discovered and remains the best characterized neurotrophin.
Each type of neurotrophin has different binding affinity toward its corresponding Trk receptor.
A composition as claimed in claim 5 further comprising a neurotrophin.
BDNF is a neurotrophin that regulates the differentiation and survival of neurons and mediates neuronal plasticity.
A composition according to claim 4, wherein said neurotrophin binds to a receptor.
Preferably, the neurotrophin is recombinantly produced.
That is, it contains domains which confer different neurotrophin specificities.
Background of invention The neurotrophin family Neurotrophins are dimeric peptide hormones.
In this embodiment, a therapeutically effective dose of a pantropic neurotrophin is administered to a patient.
Bdnf is a member of the neurotrophin family, being crucial in neurotransmitter systems.
Use according to claim 6, wherein the neurotrophic factor is a member of the neurotrophin family.
Summary of Neurotrophin family.
The use of claim 8 wherein said trophic factor is a member of the neurotrophin family.
Most preferably, the neurotrophin receptor is a trk receptor.
As one example, a macrolide or macrolide analog, may be used without a neurotrophin or neuropoietic factor.
Alternatively, the neurotrophin may be dialyzed against the refolding buffer.
Thus, in some embodiments, the nucleic acid encoding the pantropic neurotrophin includes introns.
Exemplary neurotrophin responsive cells include neurons and non-neuronal cells.
In a preferred embodiment, the pantropic neurotrophin is purified or isolated after expression.
However, the neurotrophin production / secretion promoting activity of these known compounds is so far unknown.
In the first embodiment, a domain is a portion of the neurotrophin which confers some neurotrophic specificity.
In the context of a covalent heterodimer, a domain may also refer to the entire neurotrophin monomer.
