Examples of 'neutrophil elastase' in a sentence
Meaning of "neutrophil elastase"
neutrophil elastase: is a type of enzyme released by white blood cells, specifically neutrophils, as part of the immune response. It plays a role in the body's defense mechanism against pathogens and infections
How to use "neutrophil elastase" in a sentence
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neutrophil elastase
The second substance is a human neutrophil elastase.
Neutrophil elastase activity was confirmed in EPCs conditioned media.
Its main function is to inhibit neutrophil elastase.
The effect of neutrophil elastase on fibrinolysis is less ambiguous.
Said second substance is human neutrophil elastase.
Neutrophil elastase has a wide spectrum of activities in the body.
We demonstrated that early EPCs express neutrophil elastase.
Various concentrations of the neutrophil elastase inhibitor are incubated with plasma.
Equally preferred are diseases known to be related to human neutrophil elastase.
Expression of neutrophil elastase by EPCs and enzymatic activity on adiponectin processing were assessed.
One of the enzymes found in the azurophilic granules is neutrophil elastase.
Neutrophil elastase and histone proteins have also been reported in tear fluid.
The stimulated blood is centrifuged to generate the neutrophil elastase enriched plasma.
Neutrophil elastase is a deleterious inflammatory component that is released during activation of complement.
We have now found a novel group of compounds which inhibit neutrophil elastase.
See also
The concentration of the neutrophil elastase may alternatively be measured in an aqueous assay system.
The compounds of the invention are extremely potent and highly selective inhibitors of neutrophil elastase.
Neutrophil elastase causes degradation of protease inhibitors responsible for suppressing the coagulation cascade.
Antibodies raised against human neutrophil elastase are commercially available from MP Biomedicals.
Most preferably, said second substance is human neutrophil elastase.
Human neutrophil elastase has been shown to degrade many of the supportive tissues surrounding a tooth.
In a normal lung, the alveoli are exposed to low levels of neutrophil elastase.
Inhibition of neutrophil elastase is a functional assay for detecting AAT activity in in vitro.
Moreover, genetic deficiency or pharmacological inhibition of neutrophil elastase prevented liver damage.
Human Neutrophil elastase was purchased from Calbiochem.
Importantly, the rhAAT of the invention was shown to be active as a neutrophil elastase inhibitor.
The neutrophil elastase inhibitor may be an ophthalmically-acceptable neutrophil elastase inhibitor.
In one embodiment, the compounds are neutrophil elastase, including human neutrophil elastase inhibitors.
Figure 6 shows a graph representing the titration of a ligand for human neutrophil elastase.
In certain embodiments, the serine hydrolase is a neutrophil elastase, such as human neutrophil elastase.
The second substance is a leukocyte product, a natural serine protease, human neutrophil elastase.
By " measuring the concentration of a neutrophil elastase " we include measuring the activity of a neutrophil elastase.
According to another embodiment, the additional therapeutic agent comprises a neutrophil elastase inhibitor.
Granular staining for neutrophil elastase co-localizes with histone and nucleic acid.
Means for generating a detectable response, said second substance being a human neutrophil elastase.
In one embodiment the concentration of the neutrophil elastase is measured by a dip-stick type test.
Describes a number of genetically engineered novel proteins which inhibit human neutrophil elastase ( hNE ).
Discriminating between the activities of human neutrophil elastase and proteinase 3 using serpin-derived fluorogenic substrates.
The compounds of this invention are highly potent inhibitors of elastase, particularly human neutrophil elastase.
In vitro assays of human neutrophil elastase Assay contents,.
The compounds of formula ( I ) are particularly useful as inhibitors of human neutrophil elastase.
Figure 1C is a graph showing the inhibition of neutrophil elastase activity by AAT-Fc fusión proteins.
Alpha-1 antitrypsin AAT is a protein whose main function is the inhibition of neutrophil elastase.
Instillation of human neutrophil elastase ( HNE ) into rat lung causes acute lung damage.
Despite the nomenclature, AAT has a greater inhibitory effect on neutrophil elastase than on trypsin.
The P1-profile for human neutrophil elastase has the canonical preference for alanine and valine.
Examples include thrombin, trypsin, and human neutrophil elastase.
Cathelicidin, nuclear material, and neutrophil elastase extrude from the neutrophil to form NETs FIG.
The process of claim 50 wherein the target is human neutrophil elastase.
In some embodiments, the compounds can inhibit neutrophil elastase with high affinity and selectivity . Polymers.
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Examples of using Elastase
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Free elastase was unmeasurably low in all samples
These lipopeptides can be used as elastase inhibitors
Free elastase was immeasurably low in all samples
Examples of using Neutrophil
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The lifespan of neutrophil granulocytes is quite short
No patient was discontinued secondary to low neutrophil counts
The neutrophil count is high at all ages
