Examples of 'nfkb' in a sentence
Meaning of "nfkb"
nfkb (noun) - NF-κB (Nuclear Factor Kappa-Light-Chain-Enhancer of Activated B cells) is a protein complex that plays a crucial role in regulating the immune response and inflammation
How to use "nfkb" in a sentence
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nfkb
Methods for determining NFkB signaling are described herein.
To an increase in the nuclear translocation of the factor NFkB.
The constitutive activation of NFkB has several effects.
The NFkB pathway is therefore a potential target for treating melanoma.
This effect is mediated by inhibition of NFkB activation by policosanol.
Inhibition of NFkB binding may be determined using standard bioassay methods.
Transcription of many of these genes involves the transcription factor NFkB.
Potential therapeutic target NFkB is known to promote cell survival.
Examples may include chimeras signaling through the NFkB pathway.
The role of activated NFkB is not restricted to preventing apoptosis.
There are several possible mechanisms through which NFkB can be activated.
The basal amount of NFkB in the fibroblast nuclei is very low.
NFkB is freed to undergo nuclear translocation.
The transcription factor NFkB is constitutively expressed in the cytoplasm of cells.
NFkB localization was evaluated by immunofluorescence staining.
See also
Further supporting the potential of NFkB inhibitors as novel cancer therapies.
NFkB is a known target for hyperglycemia.
The signalling cascade induces NFkB activation and allows transcription of the luciferase reporter gene.
NFkB is widely recognized as a key regulatory molecule associated with inflammation.
All purified antibodies exhibited Tweak induced NFkB blocking activity as expected.
We also found that NFkB was inhibited by administration of the policosanol formulation described herein.
Neither exogenously added nor endogenously MIF interferes with NFkB activity.
NFkB is also a critical activator of genes involved in inflammation and immunity.
The IKK dimer then phosphorylates IkB and causes it to dissociate from NFkB.
NFkB has been implicated in mediating hepatoprotective effect vía prosurvival pathway and inhibiting apoptosis.
The REAL gene encodes one of the principle subunits of the NFkB transcription factor.
NFkB regulates many inflammation genes.
This promoter region contains NFkB recognition sequences and a GAS sequence responsive to IFNY.
This effect is referred to as the anti-apoptotic effect of NFkB.
Activated NfkB has been found in the synovium of RA patients Han et al.
The pharmaceutical composition of paragraph 3 wherein the NFkB inhibitor is sulfasalazine or rapamycin.
Bound NFkB is secondarily recognized by a specific anti-NFkB antibody.
Thus, agents capable in inhibiting NFkB induction have been evaluated in cachexia models.
As noted above for TNFa, many cancers have elevated NFkB activity.
The level of activated NFkB is preferably decreased by the compound of formula I.
In some embodiments, the decreased eNOS activity is associated with an increase in NFkB.
The effect of compound 1 on NFkB activation in human monocytes in cell culture.
Rel proteins can form dimers, the most common of which is designated NFkB.
For example, both require NFkB activation as explained further below.
The polynucleotide disrupts a nucleotide normally associated with the NFkB signaling pathway ;.
It also inhibits the NFkB protein, which plays a role in inflammation.
UM dexamethasone did not inhibit the nuclear translocation of NFkB induced by TNF-a.
Finally, NFkB is associated with control of apoptosis and in growth and differentiation.
The pharmaceutical composition of claim 1 wherein the NFkB inhibitor is sulfasalazine or rapamycin.
For example, NFkB signaling is detected using fluorescence activated cell sorting.
Following activation, IkB dissociates from NFkB and undergoes ubiquitination and degradation.
Percent NFkB Inhibition of the test sample is calculated as,.
Disrupting a nucleotide normally associated with the NFkB signaling pathway and thereby treating arthritis ;.
Phosphorylation of various TRAF proteins results in activation of both canonical and non-canonical NFkB pathways.
There was also three times less NFkB in the body, which is responsible for inflammation.
