Examples of 'paraoxonase' in a sentence
Meaning of "paraoxonase"
paraoxonase (noun): A type of enzyme found in the body that plays a role in metabolizing organophosphates. It is often studied in the context of toxicology and environmental health
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- Any of a group of enzymes that act as antioxidants
How to use "paraoxonase" in a sentence
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paraoxonase
The supernatant was considered as partially purified paraoxonase.
Paraoxonase for use in therapeutic treatment of cerebral infarction.
The physiological function of paraoxonase is not known with certainty.
Paraoxonase is a serum protein that possesses enzymatic activity.
The structure obtained does not at all correspond to human paraoxonase.
Purified paraoxonase inhibited the biologic activity of these oxidized phospholipids.
Pharmaceutical formulations comprising paraoxonase.
The arylesterase activity of paraoxonase is usually measured through hydrolysis of phenylacetate.
The following conditions have been used for the detection of paraoxonase in plasma.
This reaction is used to measure paraoxonase activity in fundamental and clinical research.
There exists a need for substrates with high specificity for OPH and paraoxonase.
The apparent molecular mass of serum paraoxonase varies as the result of heterogeneous glycosylation.
DEPFMU was specifically hydrolyzed by paraoxonase.
The rabbit recombinant paraoxonase was expressed in CHO cells and partially purified.
Also provided is a method for detecting the activity of paraoxonase in an environmental sample.
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The expression of the serum paraoxonase HA protein was detected by radiolabelling and immunoprecipitation method.
The present invention provides an assay kit for paraoxonase detection and quantitation.
Partially purified recombinant paraoxonase was mixed with solutions containing different concentrations of DEPFMU as substrate.
Such samples may include those which have been treated with paraoxonase to decontaminate OPs.
Paraoxonase 3 is similar to type 1 in activity but differs from it in substrate specificity.
Similar methods can be used for detection of recombinant paraoxonase expressed in cell culture.
The serum paraoxonase gene is located close to the cystic fibrosis gene on chromosome 7.
The proposed substrates can be used for broad screening of paraoxonase activity in human blood.
Figure 18 shows that purified paraoxonase destroys the bioactivity of the oxidized phospholipids.
Other fluids may contain culture medium from the expression of paraoxonase or mutations of paraoxonase.
An example of paraoxonase detection in different serum samples is presented in Figure 1.
One possibility is that their bodies abandoned paraoxonase when they started taking long dives.
The hydrolysis of neurotoxic organophosphates is a beneficial, fortuitous activity of paraoxonase.
They all three contain human paraoxonase and the phosphate-binding protein.
More particularly, the polypeptide of the present invention is serum paraoxonase.
Currently, the most common substrates for paraoxonase used in research are paraoxon and phenylacetate.
Figure 3 depicts the measurement of the km of DEPFMU for rabbit recombinant paraoxonase.
Alternatively OPH or paraoxonase may be immobilized on supports such as membranes, resins or dipsticks.
Combination with Paraoxonase.
Paraoxonase ( PON ) activity was measured as previously described Gan et al.
Neither the function nor natural substrate ( s ) for paraoxonase have yet been identified.
Human paraoxonase ( HPON1 ) is an OP-hydrolase which has numerous advantages.
An example of the detection of membrane-associated paraoxonase is shown in Figure 2.
Injection of purified paraoxonase protected animals against OP toxicity [ 7, 8 ].
Destruction of the PON1 gene by knock-out technology creates mice that lack paraoxonase.
Figure 4 depicts a comparison of the sensitivity of paraoxonase detection using paraoxon and DEPFMU based assays.
This method of purification is based on its co-purification with human paraoxonase PON-1.
Prenatal exposure to organophosphates, paraoxonase 1, and cognitive development in childhood.
EXAMPLE 2 This example illustrates an assay for detection of paraoxonase activity.
Additional nucleotides corresponding to serum paraoxonase were added to the 5 ' and 3 ' sequences respectively.
The use of claim 1 wherein said PON-1 comprises recombinant human paraoxonase.
The primary activity of the anti-atherosclerotic paraoxonase ( PON ) enzymes is as lactonase.
Paraoxonase ( PON ) is a calcium-dependent aryl esterase ( AE ) present in plasma.
Figure 20 shows that D-4F prevents the decrease in paraoxonase activity after Influenza A infection.
Pomegranate increases the activity of the enzyme paraoxonase ( PON-1 ).
