Examples of 'pegylation' in a sentence
Meaning of "pegylation"
Pegylation (noun) - a process in biochemistry where a molecule is attached to a polyethylene glycol chain for various purposes such as drug delivery
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- The process of covalent attachment of PEG (polyethylene glycol) polymer chains to another molecule, normally a drug or therapeutic protein.
- Alternative form of PEGylation
How to use "pegylation" in a sentence
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pegylation
Various PEGylation chemistries are known in the art.
Localization of the site of pegylation by peptide mapping.
Such an antagonist may be modified by acetylation or pegylation.
Additional aspects of pegylation are described further hereafter.
Silica shell growth on nanoparticles prior to PEGylation.
This confirms PEGylation of the heavy chain.
Pegylation is used to improve the efficacy of protein pharmaceuticals.
The therapeutic value of pegylation molecules is well validated.
The PEGylation reactions are normally run at room temperature.
Have provided a review of the effects of PEGylation on pharmaceuticals.
Effect of PEGylation on the salting out of a domain antibody.
Such a fusión polypeptide may be modified by acetylation or pegylation.
Exemplary pegylation conditions are described herein.
Another modification of the antibodies described herein is pegylation.
The amount of PEGylation can be measured by known techniques.
See also
Important clinical advantages are gained by pegylation.
Chemistries for accomplishing PEGylation are discussed in more detail within.
Pegylation reduces the loss of high molecular weight species.
The specificity of the pegylation reaction was evaluated by peptide mapping.
Pegylation changes physicochemical and biological properties of the protein.
Numerous reagents for PEGylation have been described in the art.
This process is called PEGylation.
Selective covalent PEGylation may be used to minimize adverse effects.
There are several parameters to consider when developing a PEGylation procedure.
The degree of PEGylation of the protein was assessed by gel electrophoresis.
This uptake was significantly reduced by PEGylation of the liposome surface.
Another modification of the antibodies herein that is contemplated is pegylation.
Pegylation does not affect the manner of binding of interferon to its receptor.
Within another embodiment the antibody further comprises PEGylation.
Preliminary PEGylation studies.
Pegylation of recombinant blood coagulation factors in the presence of bound antibodies.
The reaction solution was mildly agitated during the pegylation reaction.
General pegylation strategies known in the art can be applied herein.
Suitable conditions for a desired degree of pegylation can be determined empirically.
The process of pegylation is known to the person of skill in the art.
The reaction solution is mildly agitated during the pegylation reaction.
The pegylation may be used to alter the in vivo circulation of a nanoparticle.
The extra lysine residue provided an additional potential PEGylation site.
Pegylation also can be used in the delivery of nucleic acid molecules in vivo.
The same samples were also analyzed by mass spectrometry prior to PEGylation.
Protein conjugates for trypsin mediated pegylation by transamidation and methods.
Methods of pegylation are commonly known in the art and detailed in the examples.
The reaction solution can be mildly agitated during the pegylation reaction.
This allowed for reproducible PEGylation and pharmacokinetics from lot to lot.
Pegylation can also help to improve the water solubility to hydrophobic polypeptides.
Another modification of the antibodies herein that is contemplated by this disclosure is pegylation.
The ability of pegylation techniques to affect protein immunogenicity has also been shown.
Another modification of the antibodies herein that is contemplated by the invention is pegylation.
The extend of PEGylation on each individual argininosuccinate synthetase molecule optionally varies.
Exemplary conjugation includes without limitation PEGylation and attaching to radioactive isotopes.
