Examples of 'pemetrexed diacid' in a sentence
Meaning of "pemetrexed diacid"
pemetrexed diacid: a chemical compound likely used in pharmaceuticals or research
How to use "pemetrexed diacid" in a sentence
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pemetrexed diacid
The recovered pemetrexed diacid may be washed with water.
The invention also encompasses a process for preparing the above crystalline pemetrexed diacid.
The recovered pemetrexed diacid may be washed with ethanol.
The present invention also provides a process for preparing the crystalline pemetrexed diacid Form A.
Preferably the starting pemetrexed diacid salt is a mono salt.
The pemetrexed diacid may be obtained by any method known to a skilled artisan.
The recovered crystalline pemetrexed diacid may then be dried.
The invention also encompasses another process for preparing the crystalline pemetrexed diacid Form B.
The recovered crystalline pemetrexed diacid may be washed and dried.
Thus, there is a need in the art for polymorphic forms of pemetrexed diacid.
The crystalline form of pemetrexed diacid can be heated in one step or gradually.
Typically, the addition of the acid induces precipitation of the crystalline pemetrexed diacid.
Crystalline form of pemetrexed diacid and process for the preparation thereof.
Typically, the acid neutralizes the salt, providing a suspension comprising free pemetrexed diacid.
Crystalline forms of pemetrexed diacid and processes for the preparation thereof.
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Typically, the suspension is maintained to increase the yield of the precipitated crystalline pemetrexed diacid.
The recovered pemetrexed diacid may be dried under vacuum with heating.
In another embodiment, the invention encompasses a process for preparing the above crystalline pemetrexed diacid.
The starting pemetrexed diacid may be prepared according to any process known to a skilled artisan.
Such methods include filtering the crystalline pemetrexed diacid from the slurry, followed by drying.
The starting pemetrexed diacid salt can be an acid-addition salt or a base-addition salt.
The X-ray powder diffraction pattern of the dried crystalline pemetrexed diacid was measured.
The obtained crystalline pemetrexed diacid may be recovered by any method known to a skilled artisan.
One ml of concentrate contains 25 mg pemetrexed as pemetrexed diacid.
The crystalline pemetrexed diacid Form G is an anhydrous form of pemetrexed diacid.
One ml contains 25 mg pemetrexed as pemetrexed diacid.
The crystalline pemetrexed diacid Form B is a hydrated form of pemetrexed diacid.
Each vial contains 100 mg of pemetrexed as pemetrexed diacid.
This crystalline pemetrexed diacid can be designated as Form G.
Optionally, the washed crystalline pemetrexed diacid may be dried prior to slurrying it.
The crystalline pemetrexed diacid Form A is a hydrated form, and preferably a dihydrated form.
Preferably, the purified crystalline pemetrexed diacid is recovered from the slurry by filtration.
The crystalline pemetrexed diacid Form E is a solvated form of pemetrexed diacid, and preferably a DMF solvate.
The process comprises crystallizing pemetrexed diacid from an aqueous solvent at a pH of about 4.5.
The recovered crystalline pemetrexed diacid may optionally be further purified by slurrying in the anti-solvent.
Preferably, the recovered crystalline pemetrexed diacid is washed with the anti-solvent prior to slurrying it.
Preferably, the crystalline pemetrexed diacid is recovered from the suspension by filtration.
The PXRD pattern of the dried pemetrexed diacid was measured and illustrated in Figure 7.
More preferably, the starting crystalline pemetrexed diacid is slurried in about 7 to 8 volumes of water.
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Examples of using Diacid
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The diacid is preferentially a polymerized fatty acid
Most preferably the diacid is adipic acid
The diacid is washed with cold water
Examples of using Pemetrexed
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Pemetrexed is primarily eliminated unchanged by renal excretion
Side effects with pemetrexed may include
Pemetrexed can have genetically damaging effects
