Examples of 'perampanel' in a sentence
Meaning of "perampanel"
Perampanel - (noun) is a medication used to treat seizures in epilepsy
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- An antiepileptic drug.
How to use "perampanel" in a sentence
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perampanel
Perampanel is usually taken time a day at bedtime.
It is not known whether perampanel is excreted in human milk.
Perampanel is dosed to clinical effect regardless of other AEDs.
Fycompa contains a medicine called perampanel.
The effect of perampanel on monohydroxycarbazepine concentrations is not known.
There is no available specific antidote to the effects of perampanel.
The effect of perampanel on human fertility has not been established.
There is limited clinical experience with perampanel overdose in humans.
Perampanel is largely metabolized by primary oxidation and subsequent glucuronation.
There were no changes directly attributable to perampanel in clinical pathology or histopathology.
Fycompa is a medicine that contains the active substance perampanel.
Perampanel is extensively metabolised via primary oxidation and sequential glucuronidation.
The active substance is perampanel.
The efficacy of perampanel in the treatment of absence seizures has not been demonstrated.
Participated in previous perampanel studies.
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The pharmacokinetics of perampanel have not been formally evaluated in patients with renal impairment.
Multiple dosing of perampanel.
Nonclinical data reveal that perampanel was not genotoxic and had no carcinogenic potential.
Aggressive and hostile behaviour has been reported in patients receiving perampanel therapy.
The efficacy and safety of perampanel in patients with myoclonic seizures have not been established.
The above described processes require many reaction steps and provide Perampanel in pure yield.
Perampanel did not affect NMDA receptor currents.
The present invention encompasses crystalline Perampanel form II that is polymorphically pure.
The present disclosure further describes a process for preparing crystalline Perampanel form II.
In both analyses, perampanel exposure is correlated with reduction in seizure frequency.
Psychomotor performance testing returned to baseline within 2 weeks of cessation of perampanel dosing.
In vivo, perampanel significantly prolonged seizure latency in an AMPA-induced seizure model.
In view of its long half-life, the effects caused by perampanel could be prolonged.
Following administration of radiolabeled perampanel, only trace amounts of perampanel metabolites were observed in plasma.
Perampanel dosing for patients with mild and moderate impairment should not exceed 8 mg.
The said process comprises crystallizing Perampanel from a mixture of solvent and anti-solvent.
The number of perampanel subjects taking enzyme inducing anti-epileptic medicinal products was small n 9.
What Fycompa contains - The active substance is perampanel.
Long-term treatment with perampanel also led to a visible improvement in motor function in treated mice.
The product was tested by PXRD - crystalline Perampanel form I was obtained.
Perampanel for epilepsy, Still no proof of added benefit.
Each film-coated tablet contains 8 mg perampanel.
Crystalline Perampanel form II was obtained, and the PXRD pattern is shown in Figure 9.
Fycompa 8 mg tablets Perampanel.
Effect of perampanel on CYP3A substrates.
Effect of cytochrome P450 inhibitors on perampanel pharmacokinetics.
Perampanel has a prolonged terminal half-life in humans of approximately 105 hours.
The mean apparent clearance of unbound perampanel in mildly impaired subjects was 188 ml / min vs.
In vitro, perampanel inhibited AMPA-induced ( but not NMDA-induced ) increase in intracellular calcium.
Data from in vitro studies indicate that perampanel is approximately 95 % bound to plasma proteins.
Perampanel - antiepileptic drug that could prevent the toxic accumulation of TDP-43.
The temperature during the addition of the Perampanel solution was kept at about -15 °C to 5 °C.
The number of perampanel subjects taking enzyme-inducing anti-epileptic medicinal products was small ( n = 9 ).
Effect of cytochrome P450 inducers on perampanel pharmacokinetics.
In vitro, perampanel inhibited AMPA - induced ( but not NMDA-induced ) increase in intracellular calcium.
