Examples of 'peroxynitrite' in a sentence
Meaning of "peroxynitrite"
peroxynitrite (verb): A reactive nitrogen species formed in biological systems, often associated with cell damage and apoptosis
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- The unstable oxyanion O=N-O-O⁻, a structural isomer of the nitrate anion; it exhibits cis-trans isomerism
How to use "peroxynitrite" in a sentence
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peroxynitrite
Peroxynitrite is a powerful oxidant and a nitrating agent.
Protein nitrosylation is an indicator of peroxynitrite formation in vascular tissue.
Peroxynitrite is formed when superoxide combines with nitric oxide.
Her thesis focused on the biological chemistry of peroxynitrite.
Role of peroxynitrite and macrophages in newborn pulmonary vascular remodeling.
This could allow the easiest access by the attacking peroxynitrite.
Pyrrolidine dithiocarbamate suppresses peroxynitrite by acting as an antioxidant against peroxynitrite.
Peroxynitrite is thus a useful tool in the fight against infectious bacteria.
Such an oxidant occurs most likely through peroxynitrite or possibly hypochlorite.
Peroxynitrite is formed by the reaction of nitric oxide with superoxide anions.
Inadequate antioxidant reserves result in peroxynitrite reacting with lipids to form isoprostanes.
We identified the tumor cell killing mechanism which involves peroxynitrite release.
Peroxynitrite is able to get across cell membranes to some extent through anion channels.
This can then go on to make another nasty free radical called peroxynitrite.
Nitric oxide reacts with superoxide to form peroxynitrite which is a potent bacteriocidal agent.
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Uric acid was known to reduce inflammation damage related to a compound call peroxynitrite.
A method for the detection of peroxynitrite using microchip electrophoresis with electrochemical detection has been developed.
Strong polyphenol activity is extremely important against the peroxynitrite free radical.
The reaction produces peroxynitrite and depletes the bioactivity of NO.
This substance is an excellent antioxidant that can interact directly with nearby peroxynitrite.
The two free radicals combine and produce the peroxynitrite anion and the spent products.
In excess it combines with oxygen to form the potent and dangerous free radical peroxynitrite.
These data suggest that NO and peroxynitrite are formed in inflamed joints.
We studied the effect of Green tea leaf extract on peroxynitrite.
Peroxynitrite is significant in that it activates NFKB.
Tyrosine reacts with other RNS that are produced by peroxynitrite.
In this case, peroxynitrite must be scavenged.
This is reflected by the inhibition through inhibitors of NO synthase or peroxynitrite scavengers.
But as far as the toxicity of peroxynitrite is concerned, there is no doubt.
Superoxide produced by activated NADPH oxidase reacts with nitric oxide to generate this peroxynitrite.
Many studies like this show peroxynitrite damages DNA.
Macrophages and T lymphocytes need nitric oxide and superoxide to produce peroxynitrite.
Alternatively, various combinations of these peroxynitrite production inhibitors can be used.
Nitrotyrosine levels were evaluated histologically ; nitrotyrosine is a marker of peroxynitrite.
Accordingly, the high level of peroxynitrite leads to apoptosis of the tumor cell.
Superoxide combines with NO to produce peroxynitrite.
This treatment, however, does not address any peroxynitrite already being formed in great quantities.
Figure 9 illustrates the inhibitory effect of green tea extract on peroxynitrite.
Although its conjugate acid is highly reactive, peroxynitrite is stable in basic solutions.
Figure 7 illustrates the luminol dependent chemiluminescence of multiple injections of peroxynitrite.
Another reaction is tyrosine nitration ; however peroxynitrite does not react directly with tyrosine.
Oxidative stress, particularly induced by superoxide, scavenges NO by forming highly reactive peroxynitrite radicals.
Either NO or peroxynitrite can cause DNA damage, which activates PARP.
It is the conjugate acid of peroxynitrite ONOO.
Peroxynitrite ( sometimes called peroxonitrite ) is an ion with the formula ONOO.
We also tried to develop " more physiological " systems of peroxynitrite generation in vitro.
Peroxynitrite was synthesized and subsequently 40µg of cardiac troponin I were nitrated with 1 mM peroxynitrite.
Cysteine-containing tripeptides showed the strong peroxynitrite scavenging activity.
Peroxynitrite can give rise to lipid peroxidation, protein nitration, DNA single-strand breakage, and guanidine nitration.
To make matters worse, reduced testosterone levels cause an increase in peroxynitrite formation.
