Examples of 'pharmacological chaperone' in a sentence
Meaning of "pharmacological chaperone"
pharmacological chaperone - a substance that assists in the folding and stabilization of proteins
How to use "pharmacological chaperone" in a sentence
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pharmacological chaperone
Method to predict response to pharmacological chaperone treatment of diseases.
A pharmacological chaperone or pharmacoperone is a drug that acts as a protein chaperone.
Indicates that the patient will respond to treatment with the specific pharmacological chaperone.
Preferably, the pharmacological chaperone is to be administered in a pharmacologically acceptable carrier.
The kit may also include inactive dosage forms that do not include the pharmacological chaperone.
In yet another embodiment, the pharmacological chaperone is a mixed agonist / antagonist.
Typically, the agent according to the description is a pharmacological chaperone.
The pharmacological chaperone of claim 1, wherein the pharmacological chaperone increases production of sAPPa.
Thus, a more suitable alternative treatment is used, pharmacological chaperone therapy.
However, the pharmacological chaperone did not enhance activity of four distinct mutant a-GAL forms.
In another non-limiting embodiment, the pharmacological chaperone is an agonist of Gaa.
Preferably, the pharmacological chaperone increases trafficking of the mutant MC4R polypeptide to the cell membrane.
The method of paragraph 40 wherein the specific pharmacological chaperone is 1-deoxynorjirimycin.
NB-DGJ is a pharmacological chaperone that can also function as an SRT.
The method of paragraph 24, wherein the specific pharmacological chaperone is isofagomine.
See also
pharmacological agents
pharmacological and toxicological
pharmacological effect
pharmacological effects
pharmacological and toxicological
pharmacological effect
pharmacological effects
The pharmacological chaperone may increase mutant and / or wild-type gangliosidase and / or sialidase activity.
Preferably, the activity enhanced by the pharmacological chaperone is adenylyl cyclase activation.
A pharmacological chaperone for use according to claim 1, wherein the chaperone binds to B-hexosaminidase B.
In one non-limiting embodiment, the pharmacological chaperone is an inhibitor or antagonist of Gaa.
The method of any one of paragraphs 32, wherein the specific pharmacological chaperone is isofagomine.
In one non-limiting embodiment, the pharmacological chaperone is an inhibitor or antagonist of MC4R.
The method of claim 24, wherein the specific pharmacological chaperone is isofagomine.
In another one, non-limiting embodiment, the pharmacological chaperone may be an inhibitor of glucosidase.
The method of any one of claims 30, wherein the specific pharmacological chaperone is 1-deoxynorjirimycin.
Contacting first host cells with the pharmacological chaperone specific for a-Gal A ; and.
The method of claim 1, wherein the pharmacological chaperone is an MC4R antagonist.
In another non-limiting embodiment, the pharmacological chaperone is an agonist of MC4R.
In one aspect of the invention, the pharmacological chaperone is N-acetylglucosamine thiazoline ( NGT ).
The method of claim 1, wherein the pharmacological chaperone has a structure as depicted in Figure 16.
The method of claim 40, wherein the specific pharmacological chaperone is 1-deoxynorjirimycin.
The method of any one of claims 1-8, wherein the specific pharmacological chaperone is 1-deoxygalactonojirimycin.
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