Examples of 'phosphate backbone' in a sentence
Meaning of "phosphate backbone"
Phosphate backbone: In the context of biology or chemistry, this phrase refers to the structural component of nucleic acids, such as DNA and RNA, that provides stability and support to the molecule
How to use "phosphate backbone" in a sentence
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phosphate backbone
To shield the negative charge of phosphate backbone.
The phosphate backbone modification may be a phosphorothioate or phosphorodithioate modification.
Some of the IMPs varied in phosphate backbone composition.
Preferred stabilized oligonucleotides of the instant invention have a modified phosphate backbone.
Some also stiffen the sugar phosphate backbone further inhibiting strand displacement by the polymerase.
Oligonucleotide stabilization can be accomplished vía phosphate backbone modifications.
Backbone Modifications The phosphate backbone may further be modified in the modified nucleosides and nucleotides.
Nucleic acid stabilization can be accomplished vía phosphate backbone modifications.
Includes a phosphate backbone modification which is a phosphorothioate or phosphorodithioate modification ; or.
One type of modified backbone is a phosphate backbone modification.
A phosphate backbone modification selected from the group consisting of a phosphonate, a phosphorothioate and a phosphotriester.
The naturally occurring backbone is the sugar phosphate backbone.
A composition according to claim 10, wherein the phosphate backbone modification is phosphorothioate or phosphorodithioate.
Preferred stabilized oligonucleotides of the present invention comprise a phosphate backbone modification.
The oligonucleotide according to claim 2, wherein the phosphate backbone modification is a phosphorothioate or phosphorodithioate modification.
See also
I would now like to catalyze the rejoining of the sugar phosphate backbone here.
The use according to claim 4, wherein the phosphate backbone modification is a phosphorothioate or phosphorodithioate modification.
A preferred stabilized nucleic acid can be accomplished vía phosphate backbone modifications.
Furthermore, the phosphate backbone modification may be a 3 ' inter - nucleotide linkage modification.
In some embodiments the modified backbone is a phosphate backbone modification.
The polycation moiety binds the DNA vía electrostatic interactions with the phosphate backbone.
The 3 ' overhang comprises a deoxyribonucleotide and / or a phosphate backbone modification, preferably methylphosphonate . Modification of dsNAs.
The IEC may be any linear DNA devoid of any phosphate backbone.
The chemical modifications can be located on the phosphate backbone of the nucleotide.
The oligonucleotide can be modified at the base moiety, sugar moiety, or phosphate backbone.
Alternatively, nucleic acid stabilization can be accomplished vía phosphate backbone modifications as discussed above.
In yet another embodiment, the antisense oligonucleotide comprises at least one modified phosphate backbone.
In preferred embodiments, the siRNA does not comprise phosphate backbone modifications.
In yet another disclosure, the antisense oligonucleotide comprises at least one modified phosphate backbone.
The 5 ' overhang comprises a modified nucleotide, preferably a 2 ' - O-methyl ribonucleotide, and / or a phosphate backbone modification, preferably phosphorothioate.
In a particular embodiment of the present invention, the backbone modification is a modified sugar phosphate backbone.
Nucleic acid stabilization can also be accomplished via phosphate backbone modifications.
Nucleic acid analogs can be modified at the base moiety, sugar moiety, or phosphate backbone.
DNA is polar due to its highly charged phosphate backbone.
Prolonged immunostimulation can be obtained using stabilized oligonucleotides, where the oligonucleotide incorporates a phosphate backbone modification.
So I would like to rejoin the sugar phosphate backbone.
The IEC may not contain any antibiotic resistance genes and / or a phosphate backbone.
Alternatively, nucleic acid stabilization can be accomplished vía phosphate backbone modifications.
These data are consistent with a cooperative binding between the poly-L-lysine and the DNA phosphate backbone.
In particular, oligonucleotide stabilization can be accomplished vía phosphate backbone modifications.
A composition according to Claims 6 or 7, wherein said oligonucleotide comprises a phosphate backbone.
Alternatively, nucleic acid stabilization can be accomplished via phosphate backbone modifications.
The process of claim 53, wherein the phosphodiester backbone is a phosphate backbone.
For instance, in some embodiments at least one nucleotide has a phosphate backbone modification.
A TFD oligonucleotide is 40 to 100 nucleotides in length and has a natural phosphate backbone.
The use according to claim 1, wherein at least one nucleotide has a phosphate backbone modification.
Alternatively, AON stabilization can be accomplished vía phosphate backbone modifications.
Intermediate H-phosphonate can be oxidized to different phosphate backbone modifications.
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Examples of using Backbone
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Just grow a backbone and call her
Backbone lends support but does not involve
Public administration is the backbone of effective government
