Examples of 'phosphodiesterases' in a sentence
Meaning of "phosphodiesterases"
Phosphodiesterase is an enzyme that breaks down phosphodiester bonds, commonly found in DNA and RNA molecules
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- plural of phosphodiesterase
How to use "phosphodiesterases" in a sentence
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phosphodiesterases
Phosphodiesterases are enzymes responsible for the breakdown of cAMP.
Any inhibitors specific to phosphodiesterases can be added as needed.
These nucleotides are resistant to degradation by phosphodiesterases.
Cyclic nucleotide phosphodiesterases are a family of phosphodiesterases.
The compounds are useful as inhibitors of phosphodiesterases.
The cyclic nucleotide phosphodiesterases are often abbreviated as phosphodiesterases.
Degradation is carried out primarily by a class of enzymes known as phosphodiesterases PDEs.
Certain phosphodiesterases have been associated with cancer development.
The invention provides isolated polynucleotides encoding the novel phosphodiesterases.
Phosphodiesterases react with these molecules and deactivate them.
Isolation of phosphodiesterases.
The phosphodiesterases are expressed in osteoblasts and are involved in osteoblast differentiation.
This property is shared with dunce and is distinct from some other phosphodiesterases.
These phosphodiesterases can compete with endogenous phosphodiesterases in the individual.
Examples of modulators that decrease cAMP degradation include inhibitors of phosphodiesterases such theophylline.
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The inhibitors of phosphodiesterases are thus of interest as therapeutic agents and as pharmacological tools.
The properties of these molecules with snake venom and spleen phosphodiesterases have been investigated.
Phosphodiesterases are enzymes inactivating cyclic nucleotides such as cyclic AMP and cyclic GMP.
Defects in cyclic nucleotide phosphodiesterases have also been associated with retinal disease.
This suggests that the cDNAs of the latter inserts do not encode cAMP phosphodiesterases.
Regulating Phosphodiesterases PDEs.
PLC enzymes belong to the family of hydrolases and phosphodiesterases.
To date, eleven families of phosphodiesterases have been identified.
Cyclic GMP is also able to stimulate the activity of some phosphodiesterases.
What about phosphodiesterases in the brain?
Indeed, it acts on lipolysis by the inhibition of the phosphodiesterases.
In one embodiment, the cells provide phosphodiesterases that are abnormally active.
The advantage of a product such as compound 3 is its enzymatic cleavability by phosphodiesterases.
In another embodiment, the cells provide phosphodiesterases that are abnormally inactive.
There are at least ten families of adenylyl cyclases, and eleven families of phosphodiesterases.
The phosphodiesterases comprise more than 50 different isoenzymes distributed over eleven families.
Caffeine supplementation can also inhibit enzymes called phosphodiesterases ( PDEs ).
The two phosphodiesterases are each further purified by affinity chromatography on a column of calmodulin-Sepharose.
In addition, this analysis provided evidence for the presence of additional isoforms of phosphodiesterases.
Accordingly, cyclic nucleotide phosphodiesterases are a major target for drug action and development.
There are ten families of adenylyl cyclases, two of guanylyl cyclases, and eleven of phosphodiesterases.
Phosphodiesterases interfere with the prey 's cardiac system, mainly to lower the blood pressure.
The activities of the high - and low-Km phosphodiesterases and of adenylate cyclase were also studied.
A cellular mechanism for the inactivation of cAMP is its breakdown by cyclic nucleotide phosphodiesterases ( PDEs ).
Cyclic nucleotide phosphodiesterases ( PDEs ) are a family of enzymes that catalyse the degradation of cyclic nucleotides.
However, the invention also encompasses fragments of the variants of the phosphodiesterases as described herein.
Cyclic nucleotide phosphodiesterases ( PDEs ) have received considerable attention as molecular targets for anti-asthmatic agents.
These compounds are ring-opened through the action of phosphodiesterases which usually require one negative charge.
The sequence includes HXXDHXX, a consensus amino acid sequence in cyclic nucleotide phosphodiesterases.
Phosphodiesterases regulate cyclic AMP / GMP concentrations.
Phosphodiesterase 9A is one member of the wide family of phosphodiesterases.
Also, phosphodiesterases ( PDEs ) are known to be involved in the regulation of the cAMP system.
Its effect is more potent on PDE5 than on other known phosphodiesterases.
Phosphodiesterases 7-11 were generated from full length human recombinant clones transfected into SF9 cells.
The effect of tadalafil is more potent on PDE5 than on other phosphodiesterases.
