Examples of 'phosphorothioate' in a sentence
Meaning of "phosphorothioate"
phosphorothioate (adjective): Referring to a type of chemical compound where sulfur replaces one of the oxygen atoms in a phosphate group
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- A derivative of phosphate in which an oxygen atom is replaced with sulfur; especially such a variant of nucleic acid
How to use "phosphorothioate" in a sentence
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phosphorothioate
The most commonly used are phosphorothioate oligonucleotides.
Phosphorothioate ODNs are primarily resistant to serum nuclease.
Each internucleoside linkage is a phosphorothioate internucleoside linkage.
Phosphorothioate derivatives and acridine substituted nucleotides.
Another consideration is the inclusion of phosphorothioate bonds.
A phosphorothioate linkage is a modified internucleoside linkage.
All phosphodiester groups are replaced by phosphorothioate groups.
Phosphorothioate antisense oligonucleotides may be used.
A presently preferred deoxyribonucleotide analog is a phosphorothioate or a phosphoramidate.
The phosphorothioate linkages are represented by asterisks.
All of the internucleotide linkages are phosphorothioate linkages.
Phosphorothioate oligonucleotides are believed to operate vÃa this type of mechanism.
Suitable modified linkers include phosphorothioate linkers.
Comprises at least one phosphorothioate or phosphorodithioate backbone modification.
In another embodiment the gapmer has a phosphorothioate backbone.
See also
Phosphorothioate linkages provide several properties to antisense compounds.
Examples of modified phosphate groups are phosphorothioate or methylphosphonate.
Phosphorothioate linkages have been incorporated into antisense oligonucleotides previously.
The internucleoside linkage may be a phosphorothioate internucleoside linkage.
In one embodiment the stabilized internucleotide linkages are phosphorothioate.
Subscript s represents a phosphorothioate internucleoside linkages.
E can consist of phosphorus containing radicals such as phosphorothioate.
The sequences optionally contain phosphorothioate modified internucleotide linkages.
In one embodiment the modified internucleoside linkage is phosphorothioate.
The sequences preferably contain phosphorothioate modified internucleotide linkages.
Phosphorothioate linkages may be preferred.
In a very preferred embodiment the modification is a phosphorothioate modification.
Oligonucleotides containing phosphorothioate backbones have enhanced nuclease stability.
The internucleoside linkages of each compound are phosphorothioate throughout.
A phosphorothioate linkage in inherently chiral.
The remaining linkages may be phosphorothioate.
The phosphorothioate analog is resistant to nucleases normally present in cells.
Beaucage reagent is used as an oxidant to obtain phosphorothioate modification.
Phosphorothioate or methylimino substituted oligonucleotides will be assessed at this stage.
The internucleoside linkages are phosphorothioate linkages.
Phosphorothioate oligonucleotides can also be synthesized for antisense construction.
The polynucleotides tested were fully modified phosphorothioate oligodeoxynucleotides.
The phosphorothioate bonds were added in order to increase the nuclease resistance.
Beaucage reagent was used as an oxidant to obtain phosphorothioate modification.
Charge neutralization of the phosphorothioate bonds can be easily achieved by alkylation.
The internucleotide linkages of each compound are phosphorothioate throughout.
These phosphorothioate oligonucleotides may have the same or different sequences.
The most preferred synthetic linkages are phosphorothioate linkages.
All internucleoside linkages are phosphorothioate internucleoside linkages unless otherwise indicated.
All the antisense nucleotide sequences are phosphorothioate type.
The process for producing phosphorothioate of the present invention includes.
In other embodiments the oligonucleotide has a phosphorothioate backbone.
Both phosphorothioate and phosphodiester nucleic acids are active in immune cells.
A preferred stabilized oligonucleotide has a phosphorothioate modified backbone.
This suggests that phosphorothioate linkages are required for maximum activity.
