Examples of 'picomolar' in a sentence
Meaning of "picomolar"
Picomolar - (adjective) is a term used in scientific fields, especially in chemistry and biology, to describe a concentration level equal to one trillionth (10^-12) of a mole per liter
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- Having a concentration of one picomole per litre.
How to use "picomolar" in a sentence
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picomolar
Detection levels may be as low as the picomolar range.
An antibody with nanomolar or picomolar range affinity is considered useful as a therapeutic agent.
Typical normal blood concentration is also in the picomolar range.
They inhibit FXa with high picomolar affinity and are highly protein bound in plasma.
A contemplated compound is more usually utilized at picomolar to micromolar amounts.
Optical detection of picomolar concentrations of RNA using switches in plasmonic chirality.
A still more usual amount is about picomolar to about nanomolar.
The antibody molecules of the present invention preferably have a high binding affinity, preferably picomolar.
A more usual amount is about picomolar to about micromolar.
Furthermore, as discussed below, they were found to be biologically active at the picomolar level.
It selectively binds and neutralizes SIP with picomolar affinity in biologic matrices.
Additionally, they proved extremely sensitive, demonstrating a detection capacity at the picomolar range.
At present fMRI can not image picomolar concentrations of neurotransmitters, receptors.
The preferred binding affinity is in the nanomolar or picomolar range.
Concentrations as low as 100 picomolar of the target RNA were recognized, according to the authors.
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Many diagnostic assays require sensitivity in the picomolar or subpicomolar range.
The antibody molecules of the present invention suitably have a high binding affinity, in particular picomolar.
A fluorimeter with these characteristics may exhibit a sensitivity of between picomolar to femtomolar fluorophore concentration.
High affinity was observed in all cases, with apparent dissociation constants in the picomolar range.
In preclinical studies, GS 5885 demonstrated low picomolar potency and a favorable safety and pharmacokinetic profile.
The plasma levels of ADM are in the lower picomolar range.
For the lowest concentrations, 100 picoMolar ( pM ) for example, the detection requires the use of a scanner.
Under physiological conditions the extrinsic Xase generates only picomolar amounts of thrombin.
In one example the single domain antibodies have a high binding affinity, for example picomolar.
Affinity matured antibodies may have nanomolar or even picomolar affinities to the receptor antigen.
In human plasma, the concentration of CNP22 typically is less than five picomolar.
These compounds have been shown to have picomolar IC50 in cancer cells.
Typical normal blood concentration of glucagon in circulation is 11-17 picomolar.
As in Example 6, the concentrations ranged between 1 picomolar and 100 nanomolar effective concentration.
Many FGFs bind their respective FGFRs with very high affinities, some in the picomolar range.
Preferred affinity matured antibodies will have nanomolar or even picomolar affinities for the target antigen.
Recombinant anti-influenza antibodies representative of clonal families bind influenza virus hemaglutinins with picomolar affinities.
The concentration of Ti is about 4 picomolar in the ocean.
Moreover, enhanced potency was detected with estimated IC50 values in the picomolar range.
All peptides were added at a 420 picomolar concentration.
The typical normal blood concentration of GLP-1 in circulation is in a range of 3-85 picomolar.
The concentration of titanium is about 4 picomolar in the ocean.
The concentration of P ₅ giving half-maximal inhibition is 60 picomolar.
Typically the assay is capable of detecting toxins in picomolar concentrations, e . g.
Both proteins exhibited substantial inhibition of GDF-8 mediated signaling at picomolar concentrations.
DARPins having affinities in the single-digit nanomolar to picomolar range can be obtained.
However, the magnitude of potency to kill H929 cells was definitely in the low picomolar range.
ISOX was previously found to have a low picomolar IC50 at HDAC6.
C5a is most potent in mediating these processes, effective in picomolar quantities.
It has been shown to block the voltage-gated sodium channels at picomolar concentrations.
Typically, aptamers generated against proteins have affinities in the picomolar to low nanomolar range.
The complex of claim 4 or 5, wherein said affinity is a picomolar affinity.
Preferably the compound binds specifically to DC-SIGN and / or DC-SIGNR at nanomolar or picomolar concentrations.
Strikingly, for compounds 1 and 2, Kd values were in the picomolar range.
More preferably, the antibody binds with a Kd less than 5 picomolar ( pM ).
