Examples of 'piperazinyl' in a sentence
Meaning of "piperazinyl"
Piperazinyl relates to or contains the chemical group piperazinyl, which consists of a six-membered heterocyclic ring containing two nitrogen atoms. Piperazinyl compounds are commonly used in pharmaceuticals and organic chemistry reactions
Show more definitions
- Any radical or cation derived from piperazine
How to use "piperazinyl" in a sentence
Basic
Advanced
piperazinyl
Piperazinyl derivatives for the treatment of cancer.
Most preferably it is piperidinyl or lower alkyl piperazinyl.
Y is piperazinyl optionally substituted as described above.
Yet another embodiment is piperidinyl or piperazinyl.
Certain piperazinyl or piperidinyl derivatives have been disclosed in the literature for different uses.
Preferably said heterocyclic ring is piperazinyl.
Morpholino, pyrrolidinyl and piperazinyl groups are preferred.
More preferably the heterocyclyl group is morpholinyl or piperazinyl.
The piperidinyl, morpholinyl or piperazinyl radicals are preferred.
Especially preferred groups include piperidinyl and piperazinyl.
Of those, piperidinyl and piperazinyl are preferred.
A preferred heterocyclyl group or moiety is piperazinyl.
R6 may represent piperazinyl or pyrrolidinyl.
Yet another embodiment is piperazinyl.
The piperazinyl radical is then preferably arranged in the 2 position.
See also
Examples of such heterocyclo groups are piperazinyl and piperidinyl.
The piperazinyl optionally is substituted with one or more independently selected alkyl ; and.
This compound is used only for preparing optionally substituted piperazinyl derivatives of it.
Of the piperazinyl or piperidinyl radical are N - oxidized.
In certain embodiments the linker moiety may comprise an optionally substituted piperazinyl moiety.
Preferably, the opposite nitrogen of the piperazinyl is substituted by a methyl group.
Preferred definitions for Y are a bond or piperazinyl.
Where appropriate, the methylation of the piperazinyl radical is carried out as described above.
Pyrrolidinyl, piperidyl or morpholinyl or optionally substituted piperazinyl.
In certain embodiments the piperazinyl is N-methylpiperazinyl.
Preferred examples are morpholinyl, thiomorpholinyl, piperidinyl or piperazinyl.
In compounds of this class A is preferably a piperazinyl or piperidinyl ring, especially a piperazinyl ring.
Particularly preferred are morpholinyl, thiomorpholinyl and piperazinyl.
The piperazinyl group is preferably a 2-piperazinyl group.
The appended azolyl ring imparts potent antibacterial activity to the piperazinyl phenyl oxazolidinone template.
There can be mentioned for example, methylpiperazinyl, ethylpiperazinyl, propylpiperazinyl, phenyl piperazinyl or benzylpiperazinyl.
In one embodiment, the heterocycle is piperazinyl.
Of these, azetidinyl, pyrrolidinyl, morpholino and piperazinyl are preferred ; pyrrolidinyl is more preferred.
In some embodiments, the heterocyclyl is piperazinyl.
Preferably, pyrrolidinyl group, piperidinyl group, piperazinyl group and morpholinyl group can be mentioned.
Another non-limiting example of heterocycloalkyl includes piperazinyl.
Of these, a pyrrolidinyl, azetidinyl and piperazinyl group are more preferred.
In general, the piperidinyl derivative was superior to the corresponding piperazinyl.
In this preferred embodiment R1 is selected from piperazinyl and substituted piperazinyl.
Suitable examples of such a ring include piperidinyl, morpholinyl, and piperazinyl.
Preferred combinations of Rings A and B include phenyl and piperazinyl ; pyridyl and piperazinyl respectively.
Examplary values of the heterocyclic ring include pyrrolidinyl, piperidinyl, and piperazinyl.
Some examples are tetrahydrofuranyl, pyrrolidinyl, piperazinyl and tetrahydrothiophenyl.
Particular examples of such ring systems include pyrrolidinyl, piperidinyl, morpholinyl and piperazinyl.
Nitrogen-bound heterocyclyl such as piperazinyl or morpholinyl.
Suitable substituents for any alkyl groups include heterocyclyl groups, for example piperazinyl.
Chemically, it is classified as a piperazinyl phenothiazine.
Preferably, the heterocyclic ring is selected from the group consisting of pyrrolidinyl, piperidyl and piperazinyl.
Typical rings so formed are morpholinyl, piperazinyl and piperidinyl.
Examples of heterocycloalkyl rings are tetrahydrofuranyl, pyrrolidinyl, piperidinyl, morpholinyl, thiomorpholinyl and piperazinyl.
