Examples of 'pitolisant' in a sentence
Meaning of "pitolisant"
Pitolisant is a noun that refers to a specific drug used for treating excessive daytime sleepiness in patients with narcolepsy. It functions as an inverse agonist of the histamine H3 receptor
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- A histamine receptor antagonist 1-[3-[3-(4-chlorophenyl)propoxy]propyl]piperidine
How to use "pitolisant" in a sentence
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pitolisant
The metabolisation of pitolisant in humans is fully characterized.
Wakix contains the active ingredient pitolisant.
Pitolisant may reduce the effectiveness of hormonal contraceptives.
Wakix contains the active substance pitolisant.
Pitolisant was neither genotoxic nor carcinogenic.
Medicinal products that pitolisant may affect metabolism.
Pitolisant pharmacokinetics after repeated administration in patients with hepatic impairment has not been evaluated yet.
Medicinal products affecting pitolisant metabolism.
In clinical trials, no specific cardiac safety signal was identified at therapeutic doses of pitolisant.
The metabolisation of pitolisant in humans is not completely characterized.
The active substance is pitolisant.
Pitolisant also modulates various neurotransmitter systems, increasing acetylcholine, noradrenaline and dopamine release in the brain.
The effect of race on metabolism of pitolisant has not been evaluated.
Combination with pitolisant should be made with a careful monitoring see section 4.4.
Therefore, breastfeeding is contraindicated during treatment with pitolisant see section 4.3.
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The MWT value in the pitolisant group was 80 % higher than in the placebo group.
Paladin Labs Inc., an operating company of Endo, will be commercializing pitolisant in Canada.
Pitolisant is contra-indicated in patients with severe hepatic impairment ( Child-Pugh C ) see section.
The serum Pitolisant half-life was longer in CYP2D6 poor metabolisers compared to the extensive metabolisers.
Pitolisant ( INN ) or tiprolisant ( USAN ) is a histamine receptor inverse agonist / antagonist selective for the H3 subtype.
