Examples of 'plerixafor' in a sentence
Meaning of "plerixafor"
plerixafor (noun): A drug that is used to stimulate the production of stem cells in the bone marrow. It is commonly used in combination with other treatments for patients undergoing stem cell transplantation
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- An immunostimulant used to mobilize hematopoietic stem cells in cancer patients.
How to use "plerixafor" in a sentence
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plerixafor
It is unknown whether plerixafor is excreted in human milk.
Mozobil contains the active substance plerixafor.
Plerixafor was not genotoxic in an adequate battery of genotoxicity tests.
The major route of elimination of plerixafor is urinary.
Plerixafor is therefore contraindicated in pregnant women except in critical cases.
Carcinogenicity studies with plerixafor have not been conducted.
A population pharmacokinetic analysis showed no effect of age on pharmacokinetics of plerixafor.
The biologically active form of plerixafor is its zinc complex.
A population pharmacokinetic analysis showed no effect of gender on pharmacokinetics of plerixafor.
There are no adequate data on the use of plerixafor in pregnant women.
Plerixafor improves the release of stem cells into the blood stream mobilisation.
The active substance is plerixafor.
The exposure to plerixafor in these studies ranged from 1 to.
Mozobil is a solution for injection that contains the active substance plerixafor.
Various processes for the preparation of plerixafor have been described in literature.
See also
Mobilisation of tumor cells has occurred in patients with leukaemia treated with plerixafor.
Use of plerixafor for treating and / or preventing acute exacerbations of chronic obstructive pulmonary disease.
This duration of dosing supports clinical administration of plerixafor up to 2 weeks.
Plerixafor did not act as a substrate or inhibitor of P-glycoprotein in an in vitro study.
Complete recovery from most signs occurred within 4 hours following plerixafor administration.
However, Plerixafor is contraindicated in patients with leukemia because of mobilization of leukemic cells.
After cleaving of the tosyl groups with hydrobromic acid, plerixafor octahydrobromide is obtained.
The present invention provides an improved, commercially viable process for the preparation of plerixafor.
Nursing Women, It is not known whether plerixafor is excreted in human milk.
The possibility that plerixafor in conjunction with G-CSF can cause splenic enlargement can not be excluded.
Only one patient aged less than 2 years old was randomized to the plerixafor treatment arm.
Carcinogenicity studies with plerixafor have not been conducted . See Part II.
What Mozobil contains - The active substance is plerixafor.
Plerixafor is moderately bound to human plasma proteins up to 58.
Excretion, The major route of elimination of plerixafor is urinary.
The effects of plerixafor on male and female fertility are not known see section 5.3.
Furthermore, the CFC mobilization profile of dextran sulfate differs from the CFC mobilization with plerixafor.
Following subcutaneous injection, plerixafor is absorbed quickly and peak concentrations are reached after 30 to 60 minutes.
Each ml solution for injection contains 20 mg plerixafor.
The recommended daily dose of plerixafor by subcutaneous injection ( SC ) is,.
An increase of nonHodgkin 's lymphoma growth was noted after a continuous administration of plerixafor for 28 days.
If a third day of collection was needed, plerixafor and G-CSF dosing was extended to Day 6.
Plerixafor is rapidly absorbed following SC injection with peak concentrations reached in approximately 30-60 minutes.
There was insufficient evidence to determine whether additional plerixafor affects survival or adverse events [ 116 ].
CD34 + cells mobilised by plerixafor are functional and capable of engraftment with long-term repopulating capacity.
Based on increasing exposure with increasing body weight, the plerixafor dose should not exceed 40 mg / day.
These findings suggest that plerixafor has a low potential for involvement in P450-dependent drug-drug interactions.
One ml of solution contains 20 mg plerixafor.
Common name, plerixafor Chemical name.
Each ml contains 20 mg plerixafor.
Plerixafor is excreted via the kidneys, with 70 % of the drug being excreted within 24 hours.
Patients were primarily treated with daily doses of 0.24 mg / kg plerixafor by subcutaneous injection.
The exposure to plerixafor in these studies ranged from 1 to 7 consecutive days ( median = 2 days ).
Mozobil 20 mg / ml solution for injection Plerixafor.
Plerixafor is rapidly absorbed following subcutaneous injection, reaching peak concentrations in approximately 30-60 minutes tmax.
