Examples of 'podophyllotoxin' in a sentence
Meaning of "podophyllotoxin"
Podophyllotoxin is a noun that refers to a natural plant extract with medical applications, particularly for treating certain skin conditions and viral infections
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- A toxin obtained from the rhizomes of some South American plants that is the base of the anticancer drug etoposide.
How to use "podophyllotoxin" in a sentence
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podophyllotoxin
Use of podophyllotoxin for pregnant women is contraindicated.
Some publications mention synthetic routes wherein picropodophyllin is formed without going vía podophyllotoxin.
Podophyllotoxin is usually recommended to treat clusters of small warts.
Concomitant use with other podophyllotoxin containing preparations.
This compound was made starting with Podophyllotoxin.
It works mostly via podophyllotoxin which stops cell division.
Because of this challenge it is still more efficient to obtain podophyllotoxin from natural sources.
It has been reported that podophyllotoxin shows a cytotoxicity to some kinds of cancer cells.
Other anti-microtubule agents include podophyllotoxin.
The hydroxyl group of Podophyllotoxin was oxidized to a ketone.
Podophyllotoxin has the structure shown below,.
The podophyllum resin from which podophyllotoxin is derived has the same effect.
More specifically, this invention relates to an efficient total synthesis of podophyllotoxin.
Etoposide is a chemotherapeutic drug derived from podophyllotoxin and acts as an inhibitor of topoisomerase II.
Derivatives of podophyllotoxin are synthesized as properties of the rings and carbon 1 through 4 are diversified.
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Usually, picropodophyllin is obtained from its stereoisomer podophyllotoxin by epimerization.
Another common source of podophyllotoxin is the rhizomes of Sinopodophyllum hexandrum Royle Berberidaceae.
Condyline is a liquid solution that contains podophyllotoxin - a plant extract.
Examples of podophyllotoxin derivates include etoposide, teniposide.
Figure 1 also depicts the space structure of podophyllotoxin and picropodophyllin.
Podophyllotoxin 1 and etoposide 2 were also tested under the same conditions as standards.
In addition to anti-cancer medication, podophyllotoxin is needed to make other types of drugs.
Podophyllotoxin has for long been implicated in cancer therapy, but produced unacceptable side effects.
In some cases, the anticancer therapy comprises therapy with a podophyllotoxin derivative.
Etoposide, a member of the epipodophyllotoxin class of oncolytics, is a semisynthetic derivative of podophyllotoxin.
The compounds in accordance with the invention may be prepared from podophyllotoxin and analogues formula,.
Anti-tumour anti-tumour podophyllotoxin derivatives include etoposide and teniposide.
Example 5 This example concerns the synthesis of oxopodophyllotoxin from podophyllotoxin.
Carbamate and thiocarbamate podophyllotoxin derivatives, preparation method and pharmaceutical compositions containing them.
Figure 2A shows the structural formulas of the compounds picropodophyllin and podophyllotoxin.
Furthermore, bepridil enhances the effects of podophyllotoxin but inhibits the effect of paclitaxel.
Podophyllotoxin is the functioning agent in Condyline, and has antiviral properties when used in medicine.
The molecule of therapeutic interest may particularly be podophyllotoxin or a nitrogen-containing analog of mustard gas.
The invention relates to a method for the synthesis of gem-difluorinated C-glycoside compounds derived from podophyllotoxin.
More specifically, it is a glycoside of podophyllotoxin with a D-glucose derivative.
The method of claim 24, wherein said biologically active nucleophile is podophyllotoxin.
For instance, synthetic routes involving epimerization of podophyllotoxin into picropodophyllin are described in Angew.
In contrast, podophyllotoxin caused severe tissue reactions with necrosis, bleeding and inflammation ( Table 5 ).
Etoposide and Teniposide are derivatives of Podophyllotoxin which are widely used as anti-cancer agents.
The use of claim 56, wherein the DNA damaging agent is podophyllotoxin.
Topoisomerase II inhibitors such as anti-tumour podophyllotoxin derivatives for example etoposide or teniposide ;.
Podophyllotoxin is primarily obtained from the American Mayapple ( Podophyllum peltatum ) and a Himalayan Mayapple ( Podophyllum hexandrum ).
External applications of podophyllum resin and podophyllotoxin should be removed by washing after 1-4 hours.
Podophyllotoxin ( podofilox ) and its derivatives, etoposide and teniposide, are all cytostatic ( antimitotic ) glucosides.
Further suitable cytostatics are, inter alia, procarbacine, hydroxyurea, L-asparaginase, dacarbazine, mitotane, estramustine, or podophyllotoxin.
The synthetic route to podophyllotoxin ( which can then be isomerized to picropodophyllin ) used in Angew.
Podophyllotoxin bears four consecutive chiral centers, labelled C-1 through C-4 in the following image.
Undesired side effects of podophyllotoxin have, however, prevented its use as an anti-cancer drug.
