Examples of 'polymer conjugate' in a sentence
Meaning of "polymer conjugate"
polymer conjugate: This phrase is commonly used in chemistry and biochemistry to describe a compound formed by the bonding of a polymer with another molecule
How to use "polymer conjugate" in a sentence
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polymer conjugate
Polymer conjugate is then a polymer carrier with attached drug.
The pharmaceutical composition facilitates administration of a polymer conjugate to an organism.
The polymer conjugate may be administered once or several times a day.
The invention also provides a method of forming a polymer conjugate of a retinoic acid.
The polymer conjugate can contain one or more chiral carbon atoms.
The amount of agent present in the polymer conjugate can vary over a wide range.
The polymer conjugate is covalently attached to the opioid antagonist by a hydrolytically stable linkage.
Note that these siRNAs differ slightly from those used in the polymer conjugate experiments.
The amount of polymer conjugate placed in solution to measure solubility can also vary greatly.
SiRNAs were delivered to mice using the polymer conjugate delivery vehicle.
The polymer conjugate of claim 3 for use as an active agent in a medicament.
The invention provides a polymer conjugate comprising the structure,.
More specifically, in one aspect, the invention provides a method for preparing a polymer conjugate.
The MMC content in the polymer conjugate was analysed by UV spectroscopy.
These formulations comprise a solution or suspension of the desired multi-armed polymer conjugate or a salt thereof.
See also
In certain instances, the polymer conjugate further comprises a targeting ligand.
Preferably, the conjugate is a multi-armed polymer conjugate.
In some embodiments, a polymer conjugate described herein can be administered intravenously.
Additionally, controlled release of paclitaxel from a polymer conjugate has yet to be optimized.
Typically, the polymer conjugate is isolated by precipitation followed by filtration and drying.
Additionally, controlled release of paclitaxel from a polymer conjugate has not been optimized.
In other embodiments, the polymer conjugate of the invention may be a flexible or flowable material.
Most preferably, the drug loading for a multi-armed polymer conjugate is one hundred percent.
A multi-armed polymer conjugate structure in accordance with the invention corresponds to the following,.
In a related aspect, the invention provides a polymer conjugate comprising the structure,.
The polymer conjugate was isolated by precipitation into 30 ml of ethyl acetate.
One example of a multi-arm embodiment of the polymer conjugate of the invention has the structure,.
A polymer conjugate prepared by reacting the branched-substantially non-antigenic polymer of claim 1 with a nucleophile.
In certain embodiments, the polymer conjugate further comprises a targeting ligand.
A polymer conjugate of an indolocarbazole compound of the general formula ( I ),.
For example, in an embodiment, the polymer conjugate comprises recurring units of the formula ( III ).
A polymer conjugate of any one of Claims 1 to 5 for use in medicine.
Generally, a PEG used to prepare a GLP-1 polymer conjugate of the invention is " activated " or reactive.
The polymer conjugate of Claim 4, wherein the taxane is paclitaxel.
One illustrative multi-armed polymer conjugate structure corresponds to the following structure,.
The polymer conjugate of Claim 4, wherein the agent is an anticancer drug.
In yet another embodiment, the polymer conjugate composition further comprises a free radical scavenger.
The polymer conjugate is effective for intercellular drug delivery . EXAMPLE 18c.
The preferred polymer conjugate of formula ( III ).
The polymer conjugate of claim 9, wherein L2 is an ether or carbamate bond.
An antibody-comb polymer conjugate according to any one of claims 1 to 7, wherein M is NH.
The polymer conjugate of claim 9, wherein L1 is an amine or amide bond.
An antibody-comb polymer conjugate according to claim 6, wherein n is 2.
The polymer conjugate or the pharmaceutical composition of claim 1 or claim 2, wherein n is from 2 to 20.
An antibody-comb polymer conjugate according to any one of claims 1 to 5, wherein L is selected from,.
The polymer conjugate of claim 1 or the pharmaceutical composition of claim 2, wherein X is NH -.
The use or polymer conjugate according to Claim 11, wherein the cancer is melanoma.
The polymer conjugate according to any one of claims 15-21 for use as a medicament.
A polymer conjugate of claim 1 or 2 represented by the following formula ( III ),.
The polymer conjugate of any one of Claims 1 to 6, wherein each R6 is.
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