Examples of 'polypeptide linker' in a sentence
Meaning of "polypeptide linker"
a sequence of amino acids connecting two domains in a protein
How to use "polypeptide linker" in a sentence
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polypeptide linker
Such polypeptide linker sequences are known in the art.
The two units may be linked by a polypeptide linker.
Each polypeptide linker sequence can be selected independently.
In certain embodiments the polypeptide linker sequences are the same.
A polypeptide linker between the component proteins or polypeptides.
Also disclosed herein is where a polypeptide linker possesses conformational flexibility.
The polypeptide linker is preferably a nonhelical polypeptide linker.
The subunits of the fusión protein may be linked by a polypeptide linker sequence.
The polypeptide linker joining the LAGLIDADG subunits can be a flexible linker.
The single polypeptide chain thus comprises a pair of variable regions connected by a polypeptide linker.
The polypeptide linker joining the LAGLIDADG subunits can have a stable secondary structure.
The I region is a polypeptide linker.
Suitably, the polypeptide linker consists of hydrophilic amino acids.
In one embodiment, the linker is a polypeptide linker.
The polypeptide linker may comprise glycine and / or serine.
See also
In one embodiment, the polypeptide linker is synthetic.
In some aspects, the proteins are separated by a linker, preferably a polypeptide linker.
Suitably, the polypeptide linker comprises hydrophilic amino acids.
In some embodiments, the linker domain is a polypeptide linker.
In a further embodiment, the polypeptide linker includes a second binding moiety.
The polypeptide of claim 1, wherein said two domains are connected by a polypeptide linker.
This flexible polypeptide linker may comprise a gly-ser linker.
Preferably, said polymer moiety is connected by a polypeptide linker to a binding domain.
In some aspects, a polypeptide linker can comprise or consists of a gly-ser linker.
In one embodiment, the polymer moiety is connected by a polypeptide linker to a binding domain.
In another embodiment, a polypeptide linker comprises or consists of a gly-ser linker.
In certain embodiments, a scFv linker peptide comprises or consists of a gly-ser polypeptide linker.
In either case, the polypeptide linker is positioned between the two subunits.
In exemplary embodiments the first and second 10Fn3 domains are connected vÃa a polypeptide linker.
In one embodiment, a polypeptide linker comprises a portion of an albumin, or a variant or fragment thereof.
The 10Fn3 domains in a multivalent fibronectin based scaffold protein may be connected by a polypeptide linker.
In some aspects, the polypeptide linker comprises or consists of a gly-ser linker.
Preferably, the number of tandem repeat units within a mucin domain polypeptide linker is between 2 and 20.
Preferably, said polypeptide linker is a polypeptide linker as described in the embodiments hereinbefore.
In a preferred embodiment of the invention said polypeptide linker comprises 1 to 5 amino acid residues.
Protein or polypeptide linker molecules may be of different amino acid compositions and / or lengths.
The FVII-HC-BspEI-R primer introduces DNA encoding the polypeptide linker as well as the Fc portion.
The flexible polypeptide linker essentially comprises glycine, serine and threonine residues.
The two domains are linked by a glycine-serine polypeptide linker having SEQ ID NO, 9.
The polypeptide linker preferably comprises a plurality of amino acids such as glycine and / or serine.
These repeat proteins comprise an N-terminal repeat domain, followed by a polypeptide linker and a C-terminal Cys.
In still another embodiment, the polypeptide linker may comprise a naturally occurring polypeptide sequence.
The first and second 10Fn3 domains may be directly or indirectly linked via a polypeptide linker ( I. ).
In one embodiment, the polypeptide linker is admixed with a pharmaceutically acceptable carrier, excipient, or diluent.
The nucleic acid of claim 1, wherein the polypeptide linker comprises SEQ ID NO, 84.
Suitably, the polypeptide linker comprises the amino acid sequence GSTSGSGKPGSGEGSTKG.
The sequence of the 217 polypeptide linker is shown in Table 3.
This polypeptide linker is also referred to as an upper hinge / linker or L1.
In some embodiments, the polypeptide linker is SEQ ID NO, 7.
In some aspects the polypeptide linker between VH2 and VL2 comprises a protease cleavage site.
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