Examples of 'pre-mrna' in a sentence
Meaning of "pre-mrna"
pre-mrna (adjective) - a term in genetics and molecular biology referring to a precursor molecule or process related to messenger RNA formation
How to use "pre-mrna" in a sentence
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pre-mrna
In eukaryotic cells the primary transcript is pre-mRNA.
The pre-mRNA molecule undergoes three main modifications.
They are generally produced from pre-mRNA introns.
The pre-mRNA of this subunit is edited at one position.
Certain antisense compounds alter splicing of pre-mRNA.
The primary transcript may be a pre-mRNA comprising introns.
Inhibitory nucleic acids are used to prevent maturation of pre-mRNA.
The pre-mRNA copy is spliced and the introns are removed.
A method of blocking a splicing process in a pre-mRNA molecule is disclosed.
Splicing of a dystrophin pre-mRNA occurs vÃa two sequential transesterification reactions.
This ratio is established mainly during pre-mRNA splicing.
Introns of a nuclear pre-mRNA for splicesome-mediated splicing are most preferred.
Riboswitch alternate structures affect the splicing of the pre-mRNA.
In a particularly preferred embodiment said pre-mRNA is derived from a dystrophin gene.
Alternative splicing may occur by splicing from the same pre-mRNA.
See also
First, a dose response for improvement of pre-mRNA splicing defects was measured.
It is typically not necessary to model the structure of the entire pre-mRNA.
Pre-mrna splicing is the process of intron removal and exon ligation in eukaryotes.
The other strategy targeting the mutant pre-mRNA is SMaRT.
Regulation and misregulation of pre-mRNA alternative splicing in cancer and other diseases.
It must be composed of several exons that are transcribed into a pre-mRNA molecule.
Which are excised from a pre-mRNA transcript to yield one or more mature mRNA.
Described herein are antisense oligonucleotides that are complementary to a pre-mRNA or a mature mRNA.
Polyadenylation of pre-mRNA is one important step of eukaryotic gene expression and regulation.
Antisense compounds that modulate processing of a pre-mRNA have also been reported.
In certain embodiments, antisense activity includes modulation of the splicing of pre-mRNA.
Mutations in four pre-mRNA splicing factors are known to cause autosomal dominant retinitis pigmentosa.
This enhancement is thought to be a result of a stabilization of the pre-mRNA in the nucleus.
This is because the pre-mRNA is composed of two types of regions, exons and introns.
We show here that LNAs are also very potent modulators of pre-mRNA splicing.
From this promoter one pre-mRNA is synthesized which gives different mRNAs by splicing.
The small molecules are thought to act by hybridising to specific locations on the pre-mRNA.
In a particularly preferred embodiment of the disclosure said pre-mRNA is derived from a dystrophin gene.
A preferred method, further comprises allowing translation of mRNA produced from splicing of said pre-mRNA.
Several ion channels and neurotransmitters receptors pre-mRNa are substrates for ADARs.
The pre-mRNA contains specific sequence elements that are recognized and utilized during spliceosome assembly.
A preferred strategic site is the translation-initiation site of the pre-mRNA coding strand.
This promoter drives the expression of a pre-mRNA which generates nine different mRNAs by splicing.
As another example, modulation of expression can include perturbing splice site selection of pre-mRNA processing.
In principle any mRNA produced from the pre-mRNA qualifies for this definition.
The absence of higher molecular weight bands indicate the absence of unspliced pre-mRNA molecules.
Examining histone pre-mRNA processing Wagner et al.
The commitment complex is an ATP-independent complex that commits the pre-mRNA to the splicing pathway.
Pre-mRNA must be processed for translation to proceed.
This embodiment broadens the potential for manipulation of the pre-mRNA leading to a functional protein.
Pre-mRNA splicing occurs in two sequential transesterification steps.
The AONs bind to complementary required sequences in the pre-mRNA and prevent normal splicing.
Pre-mRNA splicing involves two sequential biochemical reactions.
Also describe targeting the acceptor region of the mouse dystrophin pre-mRNA with longer antisense oligonucleotides.
In REV pre-mRNA this sequence is suboptimal and reduces splicing efficiency.
