Examples of 'proinsulin' in a sentence
Meaning of "proinsulin"
Proinsulin is a precursor of insulin that is made in the pancreas
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- A polypeptide that is the prohormone precursor of insulin
How to use "proinsulin" in a sentence
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proinsulin
Insulin is initially synthesized in the form of proinsulin.
It was noted that the proinsulin mRNA remained stable.
Insulin is initially synthesized in the pancreas as proinsulin.
Proinsulin is produced as a precursor known as preproinsulin.
A soluble capture ligand selective for intact proinsulin.
The proinsulin can be human proinsulin.
A capture binding ligand selective for intact proinsulin.
In the following for convenience proinsulin is sometimes referred to as insulin.
The proinsulin may be converted into insulin by enzymatic hydrolysis.
Immunoblot analysis was performed with monoclonal antibodies against proinsulin.
Crystalline human proinsulin and process for its production.
This procedure facilitates retention of the human proinsulin in crystalline form.
The proinsulin polypeptide can be a proinsulin analog having a leader peptide.
The primary structure of insulin and proinsulin have been widely modified.
The proinsulin molecule is larger than the active insulin molecule.
See also
The above definition of homologs of insulin applies equally to homologs of proinsulin.
The proinsulin polypeptide may be a proinsulin analog having a leader peptide.
Insulin is recombinantly produced vÃa the expression of proinsulin followed by enzymatic processing.
A particularly preferred stimulatory peptide compound is derived from human proinsulin.
It has also been found that proinsulin shows this hepatoselectivity to a smaller degree.
Proinsulin us the zymogen which is cleaved to form the active hormone insulin.
The cation of the crystalline human proinsulin is any of the aforedescribed cations.
The proinsulin produced by microorganisms is processed to insulin by the addition of proteolytic enzymes.
Slices of fetal bovine pancreas were used to study the initiation of proinsulin biosynthesis.
The proinsulin folds and binds to give the molecule its final structure.
The plasmids of the subject invention express a hybrid polypeptide comprising proinsulin.
In most cases proinsulin is produced as a hybrid protein which accumulates as intracellular precipitated protein.
The peptide compound is a modified form of proinsulin peptide derived from this region.
The proinsulin precursor of insulin is encoded by the INS gene.
This concept was simultaneously proposed for proinsulin and applied later to other polypeptide hormones.
The synthetic or recombinant peptide may or may not retain GAD activity or proinsulin activity.
The invention encompasses proinsulin peptide compounds that correspond to a native region of proinsulin.
This result indicates that K cells are process proinsulin to mature insulin.
Examples include proinsulin and proopiomelanocortin, which are both prohormones.
Insulin is synthesized as a larger precursor protein, proinsulin.
There are higher concentrations of proinsulin after meals and lower levels when a person is fasting.
C-peptide is formed during the conversion of proinsulin to insulin.
The purified insulins have less proinsulin and other impurities than the other types of insulins.
Proinsulin levels are not elevated with self-adm.
The selected mice received a final injection of proinsulin one month after the third injection.
In other specific embodiments, said protein or polypeptide is insulin or proinsulin.
Its role is limited to folding the proinsulin molecule in the B cells of the pancreas.
Figure 3 is a drawing of primary proinsulin.
O Defects in proinsulin conversion.
A buffering agent, such as triethylamine, may be added to the proinsulin solution.
Preferably, the proinsulin peptide is derived from human proinsulin.
Two antibodies specific to proinsulin were used,.
Hereafter, proinsulin can be converted into insulin in a manner known per se.
Yann Huon de Kermadec experiments with proinsulin for the Open Insulin project.
By expressing proinsulin without costimulation, the engineered plasmid leads to immune tolerance.
