Examples of 'prolyl hydroxylase' in a sentence
Meaning of "prolyl hydroxylase"
prolyl hydroxylase - Prolyl hydroxylase is an enzyme that plays a role in collagen synthesis and other biological processes in the body, particularly in the modification of proline residues in proteins
How to use "prolyl hydroxylase" in a sentence
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prolyl hydroxylase
Prolyl hydroxylase inhibitors and methods of use.
Crystalline forms of a prolyl hydroxylase inhibitor.
Prolyl hydroxylase inhibitors.
The polypeptides are said to have in particular prolyl hydroxylase activity.
Certain small molecules with Prolyl Hydroxylase antagonistic activities have been described in the literature.
A preferred compound of the invention is a compound that inhibits HIF prolyl hydroxylase activity.
Triazolopyridine compound, and action thereof as prolyl hydroxylase inhibitor and erythropoietin production inducer.
The present disclosure also relates to a method for controlling human protein HIF-1a prolyl hydroxylase.
A change in iron uptake by cells treated with prolyl hydroxylase inhibitors is determined as follows.
In some embodiments, the HIF hydroxylase enzyme is an asparaginyl hydroxylase or a prolyl hydroxylase.
Variety of assays may be used to determine the prolyl hydroxylase inhibitory activity of a compound.
A HIF-1a prolyl hydroxylase inhibitor having the formula,.
Methods of inducing enhanced erythropoiesis by inhibiting HIF prolyl hydroxylase are specifically contemplated.
In the absence of prolyl hydroxylase activity, VCB does not bind unmodified HIF1a.
The present compounds stabilize HIFa through inhibition of HIF prolyl hydroxylase activity.
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However, there remains a need for potent prolyl hydroxylase modulators with desirable pharmaceutical properties.
More specifically, this active agent preferentially acts as a prolyl hydroxylase inhibitor.
Preferably, the polypeptides have prolyl hydroxylase activity and require Fe ( II ) for activity.
The term “ plant endogenous ” shall refer to the plant 's own prolyl hydroxylase gene.
Category V of HIF-1a prolyl hydroxylase inhibitors relates to compounds having the formula,.
In a particular aspect, the compound inhibits HIF prolyl hydroxylase enzyme activity.
These may be useful as modulators of HIF ( hypoxia inducible factor ) alpha ( HIF-a ) prolyl hydroxylase.
The following are further non-limiting examples of prolyl hydroxylase inhibitors according to this category.
The following is a further non-limiting example of this category of HIF-1a prolyl hydroxylase inhibitors.
A composition comprising a HIF-1a prolyl hydroxylase inhibitor having the formula,.
After inducing anemia over a one - to four-week period, animals are administered prolyl hydroxylase inhibitors.
Mouse Hepa-1 cells are treated with prolyl hydroxylase inhibitors for up to 48 hours.
Table V provides non-limiting examples of this category of HIF-1a prolyl hydroxylase inhibitors.
Non-limiting examples of this iteration include HIF-1a prolyl hydroxylase inhibitors having the formula,.
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Prolyl hydroxylase inhibitors and methods of use
