Examples of 'prpsc' in a sentence
Meaning of "prpsc"
PRPSC is a noun and may refer to a specific term or abbreviation in a particular field
How to use "prpsc" in a sentence
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prpsc
The conformationally altered form of PrPC is PrPSc.
Each lane contains PrPSc from an individual mouse.
An example of a pathogenic conformational disease protein is PrPSc.
O development of immunocytochemistry for PrPsc as standard diagnostic method.
Preferably the antibody reacts with PrPSc.
Amplification of PrPSc by sonication cycles.
Cells were serially passaged thereafter in the absence of PrPSc.
Amplification of PrPSc in blood samples.
Which was similar to conformational changes from PrPC to PrPSc.
These PrPSc multimers may exist in blood of infected individuals.
Isolating phage which bind PrPSc protein.
No PrPsc was detected in the salt wash fractions by western blot.
Such complexing agents effectively bind to native PrPSc.
Dendritic polymers were able to clear PrPSc at concentrations which were not cytotoxic.
Ligands that bind to human PrPsc.
See also
Structural studies of PrPSc have been limited by the insolubility of the molecule.
This characteristic may be used to detect PrPSc with a bioassay.
The calibration with PrPSc provided a linear response within similar range.
The compositions described herein are generally substantially free of PrPsc.
No selectivity for the binding of PrPSc over PrPC is shown or suggested.
Also included are derivatives of the prion protein isoform PrPSc.
These results show that polyamines act on PrPSc in an acidic compartment.
Kringle region was involved in the selective binding of plasminogen to PrPSc.
Whether the interaction of branched polyamines with PrPSc is reversible is unknown.
Provided herein are molecules that specifically bind to or interact with PrPSc.
Rafts containing PrPc and PrPsc probably become clustered after endocytosis.
This method has been used to detect PrPsc in the blood.
The prpsc and prpc are widely different regarding secondary and tertiary structures.
Protease resistance is another characteristic that distinguishes PrPSc from PrPC.
Clarification of the exact mechanism of PrPSc elimination by branched polyamines is an important objective.
The complexing agent forms a complex with the native PrPSc.
The mechanism by which PrPc is converted to PrPsc may involve lipid rafts.
Preferably the antibody reacts with PrPc and with PrPSc.
Such a component might act as a chaperone for PrPSc inside endosomes or lysosomes.
Polyclonal and monoclonal antibodies were then tested for specificity to PrPSc.
Acquired prion disease results from exposure to PrPSc from an outside source.
All brain samples had previously been characterized for the presence of PrPSc.
A variety of PrPSc concentration methods have been reported with various PrPSc recovery efficiencies.
Deletion of each of the four putative helices prevented PrPSc formation.
The PrPSc content of brain homogenates was determined by western blotting according to standard methods.
It has not however been shown to remove existing PrPSc in vivo or in vitro.
The two PrPSc molecules then come apart and can go on to convert more PrPC.
The use of such will digest PrPC but not PrPSc.
Each sample was then analyzed for PrPSc and PrPC protein content by immunoblot.
The denatured samples can be used for further detection of PrPSc.
The molecular structure of PrPSc has not been fully characterized due to its aggregated nature.
These assays detect infected cells by virtue of their PrPSc content.
PrPSc precipitated by plasminogen was also observed.
Nucleic acids are another category of molecules that associated with PrPSc aggregates.
The kinetics of PrPSc elimination were assessed by Western blotting.
