Examples of 'pseudomonas exotoxin' in a sentence
Meaning of "pseudomonas exotoxin"
pseudomonas exotoxin - A type of toxin produced by the bacteria Pseudomonas, often used in scientific research and medical studies
How to use "pseudomonas exotoxin" in a sentence
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pseudomonas exotoxin
Pseudomonas exotoxin binds to receptors on mucosal membranes.
An example of such a toxin compound is a Pseudomonas exotoxin compound.
Pseudomonas exotoxin a with reduced immunogenicity.
In one embodiment the small molecule is Pseudomonas Exotoxin.
Pseudomonas exotoxin may also be used as the cytotoxic polypeptide.
This article teaches the three dimensional structure of the pseudomonas exotoxin A protein.
Pseudomonas exotoxin and Dipthteria toxin are most preferred.
Of these, saporin and pseudomonas exotoxin are preferably used.
Pseudomonas exotoxin A has the same catalytic activity as diphtheria toxin.
In preferred embodiments, the toxin is Pseudomonas exotoxin.
Is a Pseudomonas exotoxin in which domain La is lacking.
In some embodiments, the toxin is Pseudomonas exotoxin.
Pseudomonas exotoxin and staphylococcal and streptococcal superantigens, enzymes e . g.
The therapeutic agent can be a Pseudomonas exotoxin ( PE ) or cytotoxic fragment thereof.
Pseudomonas exotoxin and Dipthteria toxin, in particular, are frequently used in chimeric cytotoxins.
See also
Exemplary toxins include, but are not limited to, Pseudomonas exotoxin or diphtheria toxin.
A modified Pseudomonas exotoxin according to claim 1 or 2 wherein said exotoxin has boon genetically modified.
An isolated immunoconjugate of claim 9 wherein the toxin is Pseudomonas exotoxin or a variant thereof.
Example 15 Pseudomonas Exotoxin is prepared from native sources by standard techniques.
The polypeptide of claim 1, wherein the ligand binding moiety is bound to a Pseudomonas exotoxin molecule.
Pseudomonas exotoxin A ( PE ) is a toxin for which a detailed analysis of functional domains exists.
Immunotoxins are antibodies conjugated with cell toxins, such as Pseudomonas exotoxin and the like.
The Pseudomonas exotoxin ( or exotoxin A ) is an exotoxin produced by Pseudomonas aeruginosa.
Transfecting a suitable host cell with a plasmid encoding the modified Pseudomonas exotoxin as defined above ;.
Examples include ricin and Pseudomonas exotoxin A ( PE ) chimeric toxins and immunotoxins.
Culturing said host cell under conditions so that the modified Pseudomonas exotoxin is produced, and.
Pseudomonas exotoxin irreversibly inhibits protein synthesis in mammalian cells by ADP-ribosylation of elongation factor 221-22.
Such non-immunoglobulin polypeptides include polypeptide toxins such as ricin, diphtheria toxin, or Pseudomonas exotoxin.
Suitable toxins include diphtheria toxin, Pseudomonas exotoxin A, ricin, and cholera toxin.
Specifically, post immunization antisera is tested for its ability to neutralize cytotoxicity of Pseudomonas exotoxin A.
The chimeric proteins of the invention comprise a non-toxic Pseudomonas exotoxin A sequence comprising " PE translocation domain . ".
A particularly preferred conjugate is the fusión of the Mab 216 Fab2 portion with a pseudomonas exotoxin.
The present invention relates to improved Pseudomonas exotoxin A ( " PE " ) with reduced immunogenicity.
Preferably also, said toxin is an enterobacterial toxin, especially Pseudomonas exotoxin A.
The present invention provides improved Pseudomonas exotoxin A ( “ PE ” ) with reduced immunogenicity.
Also preferably, said toxin is an enterobacteria toxin, notably Pseudomonas exotoxin A.
Pseudomonas exotoxin may also be used as the cytotoxic polypeptide moiety Aiello et al ( 1995 ) Proc.
In the context of the present invention, the toxin is a mutated Pseudomonas exotoxin A.
Use of diphteria toxin ( DT ), pseudomonas exotoxin A ( PE ) and clostridium perfringens enterotoxin ( CPE ) is studied.
Examples of toxins appropriate for immunoconjugation include Pseudomonas exotoxin or ricin A-chain.
In the context of the present disclosure, the toxin is a mutated Pseudomonas exotoxin A.
Examples of suitable toxins include diphtheria toxin, Pseudomonas exotoxin A, ricin, and cholera toxin.
In the context of the present invention, the effector moiety is a mutated Pseudomonas exotoxin A.
In one embodiment of the invention, the ligand moiety is a Pseudomonas exotoxin A binding domain I.
The ribosylating activity ofPE is located between about amino acids 400 and 600 of native Pseudomonas exotoxin A.
In the most preferred embodiment, the Pseudomonas exotoxin is PE38.
In another embodiment, the compound is shiga toxin, A chain of diphtheria toxin, or Pseudomonas exotoxin A.
Examples of a compound having cell-killing activity include saporin, lysine, pseudomonas exotoxin and diphtheria toxin.
In some embodiments, the immunoconjugate may be a Fab attached to Pseudomonas exotoxin A.
In a preferred embodiment, the toxin is a Pseudomonas exotoxin ( PE ).
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Pseudomonas aeruginosa is a highly prevalent opportunistic pathogen
Resistance to fluoroquinolones is common in staphylococcus and pseudomonas
Pseudomonas aeruginosa can also be found in water
Examples of using Exotoxin
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Pseudomonas exotoxin binds to receptors on mucosal membranes
Streptolysin is a streptococcal hemolytic exotoxin
Pseudomonas exotoxin a with reduced immunogenicity
