Examples of 'pthrp' in a sentence
Meaning of "pthrp"
pthrp (adjective) - a term related to medical science referring to parathyroid hormone-related protein, which plays a role in calcium regulation in the body
How to use "pthrp" in a sentence
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pthrp
The obtained PTHrP protein is used as antigen.
A stable composition comprising pthrp and uses thereof.
Three PTHrP isoforms have been identified.
Sequences corresponding to PTHrP are shaded.
The concentration of PTHrP in the sample to be tested is shown below.
Several truncated homologs and analogs of PTHrP have been reported.
Synthesis of PTHrp by the keratinocytes.
The other function is to direct expression of carboxy terminal fragments of PTHrP.
Binding of PTHrP to its receptor alters the microenvironment of bone favorably to promote metastasis.
Sustained release compositions also include liposomally entrapped PTHrP carboxy terminal fragments.
Carboxy terminal fragments of PTHrP containing this sequence are also active in inhibiting bone resorption.
The human PTHR is a receptor which binds to both human PTH and human PTHrP.
Other workers maintain that PTHrP levels may be predictive of the progression of breast cancer.
Measurement of the Activity of the PTHrP Promoter.
Modified PTHrP peptides could be used for similar indications as PTH.
See also
Solid phase syntheses are preferred for truncated PTHrP analogs of forty or fewer amino acids.
PTHrP carboxyl terminal fragments and derivatives thereof may also be provided in a sustained release carrier.
Comparison of these bone densities showed that the PTHrP analogs had a bone healing effect.
PTHrP contains three principle domains.
The biological roles of PTHrP can be summarised as follows,.
PTHrP leads to significant increase in bone mineral density according to Pittsburgh study.
Second, the purified PTHrP protein is used as a sensitizing antigen.
PTHrP was moderately elevated.
Still, many studies focus on the role of PTHrP in breast cancer.
Moreover, PTHrP has been shown to function as an autocrine inhibitor of lymphocytes.
However, another study failed to find predictive value in PTHrP levels.
Twenty-five years of PTHrP progress, from cancer hormone to multifunctional cytokine.
Indeed, the receptor activation determines an increase in PTHrP secretion by perichondrium cells.
Thus, a lack of PTHrP could lead to the epidermal proliferation seen in psoriasis.
A stable composition comprising a bone anabolic protein, namely a pthrp analogue, and uses thereof.
Besides, the PTHrP antagonist can also be a compound reducing the expression of PTHrP.
Half of the participants received a self-administered injection of PTHrP and the other half received a placebo.
Thus, an increase in PTHrP is believed to serve as a marker for effective anti-psoriasis activity.
EXAMPLE 3 Peptides corresponding to the carboxy terminal sequence of PTHrP were synthesized as follows,.
The crude PTHrP was purified by affinity chromatography, ion exchange chromatography and gel filtration.
Therefore, some workers conclude that PTHrP levels may not be predictive of even metastasis.
PTHrP itself signals back to the prehypertrophic chondrocytes, blocking their further differentiation.
In a mouse model of MPGN, PTHrP was upregulated in the injured glomeruli at day 1.
It is thus easy to ascertain that the three lines express PTHrP and RPTH1.
Alternatively, antibodies for PTHrp can be formulated together with and administered with a bisphosphonate.
Fig . 2 is a calibration curve of measurement of PTHrP obtained in Example 1.
In addition, the PTHrP antagonist can be a non-peptidic compound that decreases the activity of PTHrP.
Thus, pVHL decreases the expression of PTHrP in CCR by destabilising the PTHrP mRNA.
Antibodies for PTHrp are preferably administered by I.V. injection in an injectable formulation.
Hence, the single amino acid switch converts inactive PTHrP into a potent PTH2 receptor agonist.
By activating PTHrp synthesis, composition A acts on the growth and differentiation of keratinocytes.
Amino acid 111 of the carboxy terminal fragment of PTHrP is generally an aromatic amino acid.
PTH and PTHrP act through a common PTH / PTHrP receptor.
A collagen-binding polypeptide segment linked to a PTH / PTHrP receptor modulator;.
Wherein the PTH / PTHrP receptor modulator is an antagonist.
