Examples of 'reduce immunogenicity' in a sentence
Meaning of "reduce immunogenicity"
reduce immunogenicity: This phrase is related to the field of immunology and refers to the process or action of decreasing the ability of a substance to produce an immune response in the body. It is often a desired outcome in medical treatments or vaccine development
How to use "reduce immunogenicity" in a sentence
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reduce immunogenicity
Chemical modification may be used to reduce immunogenicity.
Modifications to reduce immunogenicity Fc Modifications.
The advantage of chimeric antibodies is to reduce immunogenicity.
A method to reduce immunogenicity of a factor VIII molecule comprising the steps of,.
Humanization of the PARs would reduce immunogenicity in patients.
Fusion proteins with hybrid isotypes may be modified according to the invention to reduce immunogenicity.
Modifications to reduce immunogenicity.
In yet other related embodiments, the polypeptide is further modified to reduce immunogenicity.
Xenograft materials may be chemically treated to reduce immunogenicity prior to implantation into a recipient.
This includes cells that have been genetically engineered for immortalisation, or to reduce immunogenicity.
In addition, pegylation has been reported to reduce immunogenicity and toxicity of certain therapeutic proteins.
Further modifications in the variable regions can also reduce immunogenicity.
Such antibodies can reduce immunogenicity and thus avoid human anti-mouse antibody ( HAMA ) response.
The IgG variants can include modifications that reduce immunogenicity.
The compositions provided herein can be used to reduce immunogenicity of such products.
See also
Improving solution properties of proteins can increase specific enzyme activity and / or reduce immunogenicity.
PEGylation can increase solubility and stability and reduce immunogenicity of peptides and proteins.
Improving solution properties of proteins may increase specific enzyme activity and / or reduce immunogenicity.
However, reducing mutation number may reduce immunogenicity potential.
Preferably, chemical modification is used to reduce immunogenicity.
Further, it has been reported that PEGylation can reduce immunogenicity and increase solubility.
In certain embodiments, chemical modification is used to reduce immunogenicity.
PEGylated proteases can be used to reduce immunogenicity.
Moreover, either the Fab or scFv portion can be modified to reduce immunogenicity.
Such changes in the framework regions may improve stability and reduce immunogenicity of the antibody.
Preferably, chemical modification may be used to reduce immunogenicity.
But that is not all, it is also used to reduce immunogenicity.
In a preferred embodiment, the IgG variants can include modifications to reduce immunogenicity in humans.
PEG and other polymers are conjugated to recombinant proteins to reduce immunogenicity and increase half-life.
In one embodiment, the modifications improve efficacy, stability and / or reduce immunogenicity of the RNAi agent.
In some embodiments, the CAR is humanized to reduce immunogenicity ( hCAR ).
Use of soluble fragments of Hsp70 will potentially reduce immunogenicity further.
Additionally, attachment of one or more polymers ( e.g., PEGylation ) can reduce immunogenicity of protein pharmaceuticals.
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