Examples of 'rnai agent' in a sentence
Meaning of "rnai agent"
RNAi agent: Stands for Ribonucleic Acid Interference agent, which is a tool used in molecular biology to inhibit gene expression. It is commonly used in scientific research and genetic studies
How to use "rnai agent" in a sentence
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rnai agent
A method of treatment using a RNAi agent described herein.
The RNAi agent can also optionally comprise a cap.
Disclosed is one or more RNAi agent listed herein.
The RNAi agent comprises a sense strand and an antisense strand.
A preferred nucleic acid is an RNAi agent.
Disclosed is a RNAi agent as ribozyme.
A RNAi agent comprising a first and a second strand described herein.
The agent is an RNAi agent.
The RNAi agent may further comprise at least one phosphorothioate or methylphosphonate internucleotide linkage.
Administration of a RNAi agent.
RNAi agent are agents capable of triggering RNA interference.
Described are vectors comprising the double stranded RNAi agent of the invention.
Optionally, the RNAi agent further comprises a ligand.
The present disclosure encompasses modified any modified variant of any RNAi agent disclosed herein.
The pharmaceutical compositions comprising a RNAi agent can be formulated to ensure proper distribution in vivo.
See also
The present invention also provides cells comprising the double stranded RNAi agent of the invention.
In another embodiment, a RNAi agent is prepared enzymatically.
An RNAi agent comprising an anti-sense strand described herein.
In one embodiment, a RNAi agent is prepared chemically.
The RNAi agent can include an a-anomeric nucleic acid molecule.
In still another instance, a RNAi agent is a ribozyme.
A formulation as claimed in claim 5, wherein said polyanionic payload is an RNAi agent.
In still another embodiment, a RNAi agent is a ribozyme.
In one case, the RNAi agent is administered in two or more doses.
Pharmaceutical formulations of a RNAi agent to Beta-ENaC.
In some embodiments, the RNAi agent is administered using a pharmaceutical composition.
A pharmaceutical composition comprising the double stranded RNAi agent of claim 52.
In preferred embodiments, the RNAi agent is administered in a solution.
The RNAi agent may have modifications internally, or at one or both ends.
In preferred implementations, the RNAi agent is administered in a solution.
The RNAi agent may target the precursor molecule of the microRNA, known as pre-microRNA molecule.
In one embodiment, the RNAi agent comprises a blunt end.
A variety of molecules have been used for cell-specific RNAi agent delivery.
In one embodiment, the RNAi agent is administered twice per week.
Disclosed is that the composition comprises a second RNAi agent to Beta-ENaC.
In certain embodiments, the RNAi agent is administered twice per week.
In one embodiment, the composition further comprises a second RNAi agent to Beta-ENaC.
In certain cases, the RNAi agent is administered every other week.
A method of inhibiting the expression of Beta-ENaC, using a RNAi agent disclosed herein.
In one embodiment, the RNAi agent is administered in two or more doses.
In one embodiment, the disclosure comprises any one or more RNAi agent listed herein.
In certain cases, the RNAi agent is administered in two or more doses.
A pharmaceutical composition comprising the double stranded RNAi agent of any one of claims 1 to 8.
In one case, the RNAi agent is administered twice per week.
The patient can also be administered more than one RNAi agent specific to Beta-ENaC.
Alternatively, the RNAi agent can be produced from a vector, as described herein.
Typically, the kits at least include an RNAi agent as described above.
In other words, the RNAi agent may be a transcriptional template of the interfering ribonucleic acid.
In certain embodiments, the double stranded RNAi agent is administered intravenously.
In other words, the RNAi agent can be a transcriptional template of the interfering ribonucleic acid.
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