Examples of 'roflumilast' in a sentence
Meaning of "roflumilast"
roflumilast (adjective): Roflumilast is a pharmaceutical term describing a medication or drug that contains the active ingredient roflumilast, used in the treatment of certain lung conditions like chronic obstructive pulmonary disease (COPD)
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- A particular antiinflammatory drug
How to use "roflumilast" in a sentence
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roflumilast
Roflumilast for the treatment of pulmonary hypertension.
Daxas contains the active substance roflumilast.
It is not known whether roflumilast is dialysable by peritoneal dialysis.
Roflumilast is not recommended during pregnancy.
Pharmaceutical composition comprising roflumilast and levocetirizine.
Roflumilast has been demonstrated to cross the placenta in pregnant rats.
Data on the use of roflumilast in pregnant women are limited.
Roflumilast was used for the reference compound in this assay.
Libertek is a medicine that contains the active substance roflumilast.
Roflumilast is not recommended in women of childbearing potential not using contraception.
Daliresp is a medicine that contains the active substance roflumilast.
Roflumilast was the most potent inhibitor and dipyridamol was a less potent inhibitor.
Daxas is a medicine that contains the active substance roflumilast.
Roflumilast inhibits lung inflammation and emphysema in a smoking model of COPD in mice.
The active substance is roflumilast.
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Roflumilast treated COPD patients compared with COPD patients not.
Treated with roflumilast.
Roflumilast should not be used during breast-feeding.
There are limited amount of data from the use of roflumilast in pregnant women.
Roflumilast improves lung function after 6 months compared with placebo.
Sleep disturbances and mood disturbances related to roflumilast have also been reported.
Roflumilast also caused decreased infiltration of neutrophils into the airways, together with decreases in macrophages.
Available pharmacokinetic data in animals have shown excretion of roflumilast or its metabolites in milk.
Adverse reactions with roflumilast in clinical COPD studies and post-marketing experience.
What Daxas contains The active substance is roflumilast.
Coated particle according to claim 2, wherein roflumilast is suspended in the coating layer.
Coated particle according to claim 1, wherein the active ingredient is roflumilast.
These studies in rats with radiolabeled roflumilast also indicate low penetration across the blood-brain barrier.
The effects of Compound 8 were comparable to those of roflumilast.
These studies in rats with radiolabelled roflumilast also indicate low penetration across the blood-brain barrier.
According to one embodiment of the invention the PDE4 inhibitor is roflumilast.
In patients with COPD, roflumilast reduced sputum neutrophils.
What Libertek contains - The active substance is roflumilast.
Use according to claim 1 wherein roflumilast is a compound of the formula I in which.
What Daliresp contains - The active substance is roflumilast.
Use according to Claim 1, where roflumilast is a compound of the formula I in which.
Roflumilast is an example of a PDE4 inhibitor which has shown activating effects on CFTR.
Among the most advanced PDE4 inhibitors are roflumilast and cilomilast.
Roflumilast was used in Comparative Example 1.
The compounds of Examples 1 to 6 were metabolized to roflumilast by enzymes from human liver.
Roflumilast improved lung function after 4 weeks sustained over 52 weeks.
These effects of Compound 27 were comparable to those of roflumilast.
Roflumilast reduces the activity of phosphodiesterase-4, a protein occurring naturally in body cells.
Use according to claim 1, wherein the compound is Roflumilast.
The roflumilast prepared by the processes described above is distinguished by a purity of ≥ 99 % by weight.
Phosphodiesterase IV inhibitor include, for example, theophylline, cilomilast, roflumilast.
Roflumilast was used as the positive control for the study and was dosed at 5 mg / kg / day.
Phosphodiesterase IV inhibitors include, for example, theophylline, cilomilast, roflumilast.
A compound ( I ) can be manufactured by reacting roflumilast with a compound ( II ) in the presence of a base.
Thus, roflumilast treatment is not recommended in patients receiving strong cytochrome P450 enzyme inducers.
