Examples of 'sclerostin' in a sentence
Meaning of "sclerostin"
sclerostin (adjective) - pertaining to or characteristic of a protein that plays a role in the regulation of bone formation and density
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- A glycoprotein that has an antianabolic effect on bone formation.
How to use "sclerostin" in a sentence
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sclerostin
The physiological role of sclerostin remains to be elucidated.
Preferably the antibodies specifically bind to sclerostin.
A limited amount of sclerostin is then added to the wells.
Sclerostin protein is detectable predominantly in bone.
An antibody specific to sclerostin may be used to treat osteoarthritis.
Sclerostin gene expression was analyzed as follows.
Preferably the binding agents specifically bind to sclerostin.
Human sclerostin was subjected to proteolytic digestion to produce fragments.
Inhibitors may alternatively act by inhibiting expression of sclerostin.
Sclerostin was intensely expressed in developing bones of mouse embryos.
The antibody is then exposed to sclerostin bound to a chip surface.
The sclerostin binding agent of the invention preferably is an antibody.
So there is a push to find drugs that will reduce sclerostin.
Hits recognizing all sclerostin derivatives were selected and sequenced.
Provided herein are antibodies that specifically bind to human sclerostin.
See also
Sclerostin is also dispatched by bone to manage fat as an important fuel source.
Compositions and methods for use of antibodies against sclerostin.
The sclerostin inhibitor can be administered vÃa a single dose or in multiple doses.
The present invention relates generally to antibodies capable of binding to sclerostin.
Sclerostin binding antibodies.
Such inhibitors may act by binding to sclerostin or its receptor or binding partner.
Sclerostin is a potent negative regulator of bone formation in men and mice.
The sequences and mass for various human sclerostin peptides were determined.
Sclerostin binding antibody.
The mixtures were then passed over the human sclerostin coated beads.
Sclerostin binding agents.
Desuppressing these cascades vÃa removal of sclerostin may result in significantly increased mineralization activity.
Sclerostin mRNA expression is detected in adult humans predominantly in bone and kidney.
Sclerosteosis is caused by mutations in the gene that encode for the sclerostin protein.
Antibodies specific for sclerostin and methods for increasing bone mineralization.
A cell bank was generated for the purposes of screening for sclerostin neutralizing antibodies.
The amount of bound sclerostin is then measured using an appropriate sclerostin detection reagent.
SOST is a gene that encodes the protein sclerostin.
Sclerostin antibodies within this full range of potencies are suitable as neutralizing sclerostin antibodies.
The amino acid sequence of human sclerostin is reported by Brunkow et al.
Such agents can act directly or indirectly on SOST or sclerostin.
Binding to sclerostin by either noggin Fig.
Analyte Recombinant human sclerostin.
Therapeutic Uses Sclerostin functions as a negative regulator of bone formation.
Figure 9 depicts a schematic of the basic structure of human sclerostin.
Sclerostin eluted as a single peak with a slight shoulder, which was discarded.
The invention relates to antibodies, that specifically bind to sclerostin.
The composition of aspect 22 wherein said sclerostin binding agent is an antibody.
The sclerostin binding agent of aspect 1 or 3 wherein said sclerostin binding agent is an antibody.
Objective, to evaluate the serum sclerostin levels and determine association with sarcopenia.
The disclosure relates to binding agents, such as antibodies, that specifically bind to sclerostin.
An isolated complex comprising a sclerostin polypeptide and a chordin polypeptide in specific association, wherein,.
The invention relates to binding agents, such as antibodies, that specifically bind to sclerostin.
The protein levels of sclerostin in periodontal tissues were measured by enzyme-linked immunosorbent assay elisa.
The peptides generated by aspN cleavage of human sclerostin are shown in Figure 12.
