Examples of 'selexipag' in a sentence
Meaning of "selexipag"
Selexipag is a medication used to treat pulmonary arterial hypertension. It works by relaxing and widening the blood vessels in the lungs to lower blood pressure and reduce strain on the heart
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- A drug currently in development for the treatment of pulmonary arterial hypertension.
How to use "selexipag" in a sentence
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selexipag
Uptravi contains the active substance selexipag.
Administration of selexipag in the paediatric population is not recommended.
There are no data from the use of selexipag in pregnant women.
Selexipag is an inhibitor of platelet aggregation in vitro.
The active substance is selexipag.
Effect of selexipag on other medicinal products.
Uptravi is a medicine that contains the active substance selexipag.
Of patients on selexipag discontinued treatment due to these adverse reactions.
Solid state forms of selexipag.
It is unknown whether selexipag or its metabolites are excreted in human milk.
Women of childbearing potential should practise effective contraception while taking selexipag.
Selexipag and its active metabolite do not inhibit transport proteins.
The present disclosure further encompasses processes for preparing Selexipag salt or solid state forms thereof.
Selexipag is rapidly absorbed and is hydrolysed by carboxylesterases to its active metabolite.
The present disclosure describes amorphous Selexipag.
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The pharmacokinetics of selexipag and its active metabolite are not affected by warfarin.
The present disclosure comprises a crystalline form of Selexipag designated as Form IV.
Selexipag did not influence the pharmacodynamic effect of warfarin on the international normalised ratio.
The present invention comprises a crystalline form of Selexipag designated as Form IV.
The pharmacokinetics of selexipag and its active metabolite have been studied primarily in healthy subjects.
Figure 2 shows a Le-Bail fit of Synchrotron powder diffraction pattern of Selexipag Form IV.
Selexipag This medicine is subject to additional monitoring.
The increased solubility of Form IV of Selexipag may enhance bioavailability of the API.
Selexipag does not cause IP receptor desensitisation in vitro nor tachyphylaxis in a rat model.
Treatment comparison, selexipag vs placebo.
Selexipag is a selective IP receptor agonist distinct from prostacyclin and its analogues.
Concomitant administration of selexipag with CYP3A4 substrates does not require dose adjustment.
Selexipag has the following chemical structure,.
The crystalline form IV of Selexipag of claim 1, wherein the crystalline form is anhydrous.
Selexipag is a weak substrate of the P-gp efflux pump.
Alternatively, crystalline Form IV of Selexipag may be characterized by the following unit cell data,.
Selexipag undergoes enzymatic hydrolysis of the acyl sulphonamide by CES1 to yield the active metabolite.
The absolute bioavailability of selexipag in humans is approximately 49.
Uptravi film-coated tablets selexipag.
Selexipag and its active metabolite do not inhibit cytochrome P450 enzymes at clinically relevant concentrations.
Includes ‘ Need for lung transplantation or atrial septostomy ' 1 patient on selexipag and 2 on placebo.
Selexipag and its active metabolite both undergo oxidative metabolism by CYP2C8 and CYP3A4.
Only two subjects with severe ( Child-Pugh class C ) hepatic impairment were dosed with selexipag.
In rats, selexipag or its metabolites are excreted in milk see section 5.3.
Figure 4 shows a Thermogravimetric analysis thermogram ( TGA ) of form IV of Selexipag.
Selexipag is hydrolysed to its active metabolite by carboxylesterases ( see section 5.2 ).
Reference example 1, Preparation of Selexipag.
Selexipag is hydrolysed to its active metabolite by hepatic carboxylesterase 1 CES1 ; see section 5.2.
FIG . 3 shows a Differential scanning calorimetry thermogram ( DSC ) of form IV of Selexipag.
The volume of distribution of selexipag at steady state is 11.7 L.
Figure 3 shows a Differential scanning calorimetry thermogram ( DSC ) of form IV of Selexipag.
Selexipag and its active metabolite are substrates of OATP1B1 and OATP1B3.
FIG . 4 shows a Thermogravimetric analysis thermogram ( TGA ) of form IV of Selexipag.
