Examples of 'serpin' in a sentence
Meaning of "serpin"
serpin (verb): This is a term used in the field of biology, particularly in the study of serine protease inhibitors. Serpins are a family of proteins that inhibit serine proteases, enzymes involved in various biological processes such as blood clotting and immune response
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- Any of a family of proteins that inhibit serine proteases (especially trypsin)
How to use "serpin" in a sentence
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serpin
Predicted serpin genes are sporadically distributed in prokaryotes.
Several proteins related to the serpin family were also identified.
Neuroserpin is a serpin protease inhibitor family member.
This conformational rearrangement makes the serpin a more effective inhibitor.
Cl is a serpin and forms an essentially irreversible complex with pKA.
The protein encoded by this gene belongs to the serpin family.
Exemplary members of the serpin superfamily are listed in the following.
Serpin genes are a family of genes that encode serine protease inhibitors.
Myoepithelial cells seem to have the unique ability to secrete this serpin.
The serpin can be located at any position within the fusión protein.
Mutations can be made in the protease that will make it resistant to serpin inactivation.
The ovserpin family has unique characteristics among the serpin superfamily.
These methods can be used to increase or decrease the expression of the serpin polynucleotides.
The serpin superfamily is the largest and most broadly distributed of protease inhibitors.
The potency advantages are especially important in disease states in which serpin levels are elevated.
See also
Any modified serpin can be used in the selection methods herein to identify variant proteases.
Structural biology has played a central role in the understanding of serpin function and biology.
AAT is the archetypical Serpin and shares tertiary structure with other Serpins.
PA inhibitors are members of the serpin gene family.
C1 is a serpin and forms an essentially irreversible complex with pKA.
Examples of serine proteases and their cognate serpin inhibitors are listed in Table IV below.
In one example of such an assay, the protease trap is a serpin.
Vaccinia virus also contains Serpin genes and Ankyrin genes.
The action of t-PA in vivo and in vitro can be inhibited by a serpin.
Ovine uterine serpin also binds to activin, IgM and IgA.
In effect, the protease is crushed against the body of the serpin.
When a serpin inhibits a target protease, it forms a permanent complex, which needs to be disposed of.
Upon binding to a target, an irreversible change in the structure of a serpin protein occurs.
In eukaryotes, a plant serpin inhibits both metacaspases and a papain-like cysteine protease.
Table 3 depicts examples of serine proteases and their cognate serpin inhibitors.
The most stable form of the serpin structure is the RSL-cleaved form.
Different serpin-finger fusión polypeptides have been assayed for their association rate with the serpin alpha1-antitrypsin.
For example, the present disclosure includes a serpin fused to a cytokine receptor targeting antibody.
A modified serpin for use according to claim 17 wherein the individual is a trauma patient.
In a preferred aspect of the disclosure, the Serpin genes are completely truncated.
Within the cell, serpin polymers are slowly removed via degradation in the endoplasmic reticulum.
The major inhibitor of plasma kallikrein is the serpin C1 esterase inhibitor.
However, the details of how serpin polymers cause cell death remains to be fully understood.
Serpin-Fc fusión protein incorporating more than one serpin polypeptide are also represented.
In a preferred embodiment, the serpin binds heparin, and inhibits both serine protease and HIV.
The disease has been found in animals with a frameshift mutation variety of the protein Serpin B11.
First, the lack of active serpin results in uncontrolled protease activity and tissue destruction.
In some embodiments, the Polypeptide I sequence includes a serpin polypeptide.
In other aspects, the serpin polypeptide and the cytokine targeting polypeptide are directly attached.
Researchers have identified at least 37 different serpin genes in humans.
In some embodiments, the serpin-WAP domain fusión protein includes a single serpin polypeptide.
C1-inhibitor is the largest member among the serpin superfamily of proteins.
In other analyses, uterine serpins have been considered as a separate clade in the serpin superfamily.
The Drosophila melanogaster genome contains 29 serpin encoding genes.
Certain non-inhibitory serpins also use the serpin conformational change as part of their function.
