Examples of 'signaling domain' in a sentence
Meaning of "signaling domain"
signaling domain: In technical contexts, this phrase typically refers to a specific area or aspect within a system that is responsible for sending, receiving, or processing signals for communication or control purposes
How to use "signaling domain" in a sentence
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signaling domain
The costimulatory signaling domain is derived from a costimulatory molecule.
Cytoplasmic domain The cytoplasmic domain or region of the CAR includes an intracellular signaling domain.
An intracellular signaling domain.
Intracellular signaling domain The CAR of the invention may also comprise an intracellular signaling domain.
Figure 3 shows evolution of a signaling domain superfamily.
In particular examples, CARs contemplated herein comprise an intracellular signaling domain.
A costimulatory intracellular signaling domain can be derived from the intracellular portion of a costimulatory molecule.
Still more preferably, the chimeric protein also comprises a signaling domain.
The third domain is the activation signaling domain which is a cytotoxic lymphocyte activation signal.
In an instance, the antigen binding member does not comprise a co-stimulatory signaling domain.
The encoded intracellular signaling domain comprises a costimulatory signaling domain ;.
More preferably, the protein further comprises a transmembrane domain and / or a signaling domain.
The encoded intracellular signaling domain comprises a primary signaling domain ;.
The cytoplasmic domain may be designed to further comprise the signaling domain of CD3-zeta.
In one embodiment, the intracellular signaling domain comprises two costimulatory signaling domains.
See also
Chimeric antigen receptor comprises an extracellular binding domain, a transmembrane region and an intracellular signaling domain.
However, in many cases, a signaling domain from a different species can be used effectively.
In a more specific embodiment, said polypeptide sequence is a CD3Z signaling domain.
In an embodiment, the intracellular signaling domain can comprise a primary intracellular signaling domain.
In another embodiment said second polypeptide comprises a CD3Z signaling domain.
For example, the endodomain can contain an intracellular signaling domain and optionally a co-stimulatory signaling region.
Alternatively, in some embodiments, the CAR does not include a costimulatory signaling domain.
In various embodiments, the intracellular signaling domain is a E-chain signaling domain.
According to the embodiments described herein, a CAR may include at least one costimulatory signaling domain.
In one embodiment, said intracellular signaling domain comprises an ITAM motif.
Intracellular Signaling Domain In particular embodiments, CARs contemplated herein comprise an intracellular signaling domain.
In one embodiment the transmembrane and intracellular signaling domain comprise the sequence below,.
In one embodiment, said sequence encodes a DAP 12 polypeptide comprising a DAP 12 intracellular signaling domain.
In various embodiments, the intracellular signaling domain is a Z-chain signaling domain.
In one embodiment, the artificial T cell receptor of the invention comprises a T cell signaling domain.
In one instance, said intracellular signaling domain comprises an ITAM motif.
According to the embodiments described herein, a CD123CAR may include at least one costimulatory signaling domain.
In some embodiments, the intracellular signaling domain is derived from a CD3 complex.
The costimulatory domain ( s ) are located between the transmembrane domain and the CD3Z signaling domain.
The third domain is the activation signaling domain ( or T cell signaling domain ).
With respect to the cytoplasmic domain, the CAR described herein comprises the 4-1BB signaling domain.
In instances, the primary signaling domain comprises a functional signaling domain of CD3 zeta.
In an embodiment a intracellular signaling domain is DAP12.
Preferable, the intracellular signaling domain comprises the intracellular signaling domain of human CD3 zeta chain.
In one embodiment the transmembrane and intracellular signaling domain are both derived from CD28.
An exemplary primary signaling domain of a CD3zeta domain sequence is provided as SEQ ID NO, 17.
For example, the intracellular domain is a CD3 zeta signaling domain of SEQ.
In instances, the intracellular signaling domain of the CAR molecule comprises a primary signaling domain.
Alternatively, in some embodiments, the CD123CAR does not include a costimulatory signaling domain.
Finally, the endodomain represents the signaling domain in the cytoplasmic part of the CAR.
The CD28 signaling domain may include a modified CD28 transmembrane domain.
In yet another embodiment, the intracellular signaling domain is the . zeta . - chain signaling domain.
In one embodiment, the signaling domain is a CD3 zeta signaling domain.
In embodiments the primary intracellular signaling domain has at least 70, 75.
In an embodiment, a primary signaling domain comprises one, two, three, four or more ITAM motifs.
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