Examples of 'sirtuin' in a sentence
Meaning of "sirtuin"
sirtuin (verb): This term refers to the action of regulating a class of proteins that are believed to be involved in various biological processes such as aging, transcription, apoptosis, inflammation, and stress resistance
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- Any of several enzymes that act as regulatory factors that mediate the life-extending effects of a low-calorie diet.
How to use "sirtuin" in a sentence
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sirtuin
A novel strategy for discovery of sirtuin inhibitors.
Sirtuin protein linked to longevity in mammals.
Their diet is based on consuming foods rich in sirtuin activators.
Sirtuin activation was also quantified.
Nitroxoline inhibits sirtuin activities.
Sirtuin modulating compounds that exhibit large therapeutic indexes are preferred.
An exemplary assay for determining sirtuin activity is a fluorescence polarization assay.
Diagnostic methods may use an antibody that specifically binds to a sirtuin.
Each isoform of human sirtuin is known to have different substrate specificity.
Cell based assays may also be used to determine sirtuin activity.
Biologically active portions of a sirtuin may comprise the core domain of sirtuins.
A method may comprise determining the level or activity of a sirtuin protein.
Decreasing a sirtuin protein level can be achieved according to methods known in the art.
The same assay may be used to identify modulators of any sirtuin protein.
The agent can also be comprise by a sirtuin polypeptide or a nucleic acid encoding a sirtuin polypeptide.
See also
These effects of resveratrol are largely mediated by members of the sirtuin family of proteins.
Sirtuins for use in the assays may be full length sirtuin proteins or portions thereof.
Research is currently underway to develop compounds effective at increasing sirtuin levels in the body.
Pharmacological regulation of certain sirtuin proteins and the use of spermidine and other epigenetic modulators.
Methods for enhancing muscle performance comprise administering a therapeutically effective amount of a sirtuin activating compound.
Nor Frye test sirtuin deacetylase activity on a cellular polypeptide.
This diet involves foods with huge amounts of Sirtuin activators.
Our Sirtuin Inhibitor products is good in quality and competitive in price.
Assays Various types of assays to determine sirtuin activity have been described.
The sirtuin protein is a mammalian protein ;.
The protein encoded by this gene is included in class I of the sirtuin family.
Examples of cell based assays for determining sirtuin activity are described in PCT Publication Nos.
Sirtuin activators are now being tested in humans as anti-diabetic compounds.
SUMMARY Provided herein are compounds which are sirtuin modulators.
A " direct inhibitor " of a sirtuin is a molecule inhibits a sirtuin by binding to it.
May promote lifespan via activation of sirtuin 1 gene.
A " direct activator " of a sirtuin is a molecule that activates a sirtuin by binding to it.
The compound increases deacetylase activity of the sirtuin protein ;.
Sirtuin 6 activating peptides and cosmetic or pharmaceutical composition containing them.
Several previous studies suggested that resveratrol 's primary target is sirtuin 1.
Sirtuin-modulating compounds may act to modulate a sirtuin protein either directly or indirectly.
In some embodiments, the nanolipogel includes a moiety that specifically targets a sirtuin.
In certain embodiments, sirtuin modulating compounds may be useful for treatment mitochondrial myopathies.
Unfortunately the current high-throughput assays for discovery of sirtuin inhibitors suffer from important limitations.
In other embodiments, sirtuin activity may be determined using a mass spectrometry based assays.
The authors present evidence that resveratrol does not directly activate sirtuin 1, a protein associated with aging.
In addition, the sirtuin 6 expression stimulation effect was maintained for the long term.
B, Effect of nitroxoline on sirtuin activities.
Sirtuins are present in all living organisms, with humans having seven different sirtuin proteins.
In a preferred instance, the target is an antisense polynucleotide of the Sirtuin 1 gene.
In certain embodiments, a sirtuin-modulating compound does not have any substantial ability to modulate sirtuin homologs.
Studies show that resveratrol activates SIRT1, one of many in the Sirtuin family of enzymes.
The combination of elevated sirtuin activity and increased NAD+ synthesis boosted mitochondrial activity.
The company Sirtris, meanwhile, has been testing resveratrol and other drugs that activate sirtuin.
Resveratrol also activates the sirtuin family of enzymes, most notably the SIRT1 enzyme.
