Examples of 'slow off-rate' in a sentence
Meaning of "slow off-rate"
Slow off-rate: In the context of biochemistry, slow off-rate refers to the rate at which a ligand dissociates from its binding site on a protein or enzyme, typically indicating a stable and long-lasting interaction
How to use "slow off-rate" in a sentence
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slow off-rate
Slow off-rate aptamers can be used in a method of treatment of disease.
Example 6 describes the generation of a slow off-rate aptamer to a peptide target.
The slow off-rate aptamers may be used in therapeutic imaging studies.
Example 7 illustrates the utility of slow off-rate aptamers relative to conventional aptamers.
Slow off-rate aptamers can be used in a method for diagnosis of disease in vivo.
In another embodiment, the slow off-rate aptamers are mixed or exposed to a sample.
Slow off-rate aptamers will bind to the target for a longer duration.
Example 8 illustrates the generation of slow off-rate aptamers using a BndU candidate mixture.
The slow off-rate aptamer may be labeled with a diamagnetic or paramagnetic material.
Example 5 describes the generation of slow off-rate aptamers using a NpdUTP candidate mixture.
Slow off-rate aptamers can be used in vitro for the diagnosis of disease.
In another embodiment, complexes including a slow off-rate aptamer and a target molecule are provided.
Slow off-rate aptamers could be produced to differentiate the type or level of modification.
In certain embodiments, the method further includes performing a slow off-rate enrichment process.
Optionally these slow off-rate aptamers may be photoaptamers or crosslinking aptamers.
See also
In any of the embodiments described herein, each aptamer may be a slow off-rate aptamer.
In one embodiment, slow off-rate aptamers can be used in a method of treatment of disease.
In certain methods, the method further includes performing a slow off-rate enrichment process.
In one embodiment, slow off-rate aptamers are suitable reagents for molecular imaging in vivo.
The sensitivity of detection of the respective targets with the slow off-rate aptamers is excellent.
In addition, slow off-rate aptamers to various targets such as proteins and peptides are described.
This process may be also include the use of the slow off-rate enrichment process.
Optionally these slow off-rate aptamers may be designed to crosslink to their specific target.
This additional step would insure that the final selected slow off-rate aptamer was highly specific.
The slow off-rate aptamers may optionally be designed to crosslink with their specific target.
These candidate mixtures are used in a SELEX process to identify slow off-rate aptamers.
Slow off-rate aptamers with unique structural features and melting temperatures are also described.
In some embodiments, at least one aptamer is a slow off-rate aptamer.
As mentioned above, these slow off-rate aptamers are known as “ SOMAmers . ”.
Example 4 illustrates the effectiveness of the slow off-rate enrichment process.
The average for aptamers selected with a slow off-rate enrichment process was over 85 minutes.
Dissociation half-life values ( t1/2 ) of aptamers using the competitor slow off-rate enrichment step protocol.
FIGS . 12 A and 12B illustrate performance curves for a slow off-rate aptamer where the target was a peptide.
Example 9 describes the generation and histological applications of slow off-rate BndU aptamers to Her2 ( ErbB-2 ).
In some embodiments, the reversible kinase inhibitor has a slow off rate ( a slow off-rate inhibitor ).
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Or a slow death along with your mates
Maybe you should slow it down a bit
Slow start disabled at the sewing start
