Examples of 'smac' in a sentence
Meaning of "smac"
The phrase 'smac' is an adjective used in informal contexts to describe something stylish, fashionable, or cool
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- Abbreviation of second mitochondria-derived activator of caspases (“Diablo homolog”)., a component of the apoptosis pathway.
- Abbreviation of supramolecular activation cluster., the structure comprising the immunological synapse
- Sequential Multiple Analysis - Computer or comprehensive metabolic panel, a panel of clinical chemistry lab tests.
- social, mobile, analytics, cloud: a group of technologies
How to use "smac" in a sentence
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Smac mimetics are preferably administered in effective amounts.
Intermediates for the preparation of bivalent smac mimetics.
Smac appears to be a regulator of apoptosis in mammals.
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Smac mimetics may also be used to treat autoimmune diseases.
The recombinant Smac was purified to homogeneity.
Smac mimetics as described herein may also be administered concurrently with immunotherapeutic agents.
The expression of recombinant Smac was analyzed by western blot.
Smac also allows caspase activation in the presence of physiological levels of potassium salt.
One embodiment of the invention is the therapeutic composition of a Smac mimetic.
This purified Smac fusión protein was used to generate polyclonal antibody by immunizing rabbits.
Also discussed is a method of inhibiting tumor growth in vivo by administering a Smac peptidomimetic.
The linker is used to join two Smac mimetic compounds into a bivalent structure.
Similar tests were performed with the combination of carboplatin and Smac mimetics.
Smac mimetics may be used in combination with BCG vaccine treatment of bladder cancer.
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These data were generated by testing various concentrations of cisplatin and Smac mimetics drugs.
Smac shares footage and photographs of the damage the Irish vessel had encountered here.
The compounds encompassed in the present invention include both Smac mimetics and intermediates therefor.
Smac is a potent endogenous inhibitor of XIAP.
Who should take over Smac.
Smac peptidomimetic, which is preferably isotonic with the blood of the recipient.
Transfection of HeLa Cells with Smac cDNA.
Thus, Smac appears to be a master regulator of apoptosis in mammals.
Purification of Smac.
The FLAG-tagged Smac was exclusively localized in mitochondria.
In particular, the invention relates to intermediates for the preparation of bivalent Smac mimetics.
In living cells, Smac and cytochrome c were exclusively localized in mitochondrial fractions.
These data were generated by testing various concentrations ofa common taxane, paclitaxel, and a Smac mimetic.
Of significance, Smac peptide does not have detectable toxicity to normal brain tissue.
The compounds also inhibit the binding of ML-IAP to Smac protein.
In a further example, the Smac mimetics do not contain any peptide bonds.
Thus Hid, Grim, and Reaper represent the functional homologs of the mammalian protein Smac.
XSP, the nominal target of Smac mimetics, is overexpressed in a high proportion of bladder cancers.
Fractions of 10 ml were collected and assayed for Smac activity.
Examples of known Smac mimetic compounds that are useful as starting materials include the following,.
A protein band that migrated at 25 kDa correlated with the Smac activity.
Administration of the Smac peptidomimetic may occur prior to, concurrently with the treatment protocol.
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In another example, the Smac mimetics do not contain any naturally occurring amino acids.
Figure 9 . - Concentration dependent cytotoxic response of Smac cells upon Tamoxifen treatments.
Transiently expressed Smac in cells did not induce caspase-3 activation and apoptosis without apoptotic stimuli.
Fractions of 4-ml were collected starting from 90-ml of elution and assayed for Smac activity.
Today, Colas completed the sale of Smac to a subsidiary of OpenGate Capital.
Smac mRNA expression is low in brain, lung, thymus, and peripheral blood leukocytes.
In Waterproofing, an agreement to sell Smac was signed with the investment fund OpenGate Capital.
Anti-Smac anti-serum was generated by immunizing rabbits with a recombinant Smac fusión protein ( see above ).
The IV dose for each Smac mimetic was 1 mg / kg.
The Smac PRO40 has an advanced visual and auditive monitoring system.
The synergy with paclitaxel and the Smac peptidomimetic Entry 122 in OVCAR3 cells was tested.
In all tissues examined, a predominant mRNA of ~ 1.5kb was detected, indicating ubiquitous expression of Smac.
