Examples of 'small molecule inhibitors' in a sentence
Meaning of "small molecule inhibitors"
small molecule inhibitors: Small molecule inhibitors are compounds that can bind to specific target molecules, such as proteins, and inhibit their biological activity. They are commonly used in the field of pharmacology to block the function of certain enzymes or signaling pathways, often as a therapeutic strategy for treating diseases
How to use "small molecule inhibitors" in a sentence
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small molecule inhibitors
Also contemplated are small molecule inhibitors.
Small molecule inhibitors can be designed using computational approaches.
We have identified novel small molecule inhibitors of leukemic stem cells.
Small molecule inhibitors of tyrosine kinases are known in the art.
It is in this catalytic region where small molecule inhibitors can bind.
Several small molecule inhibitors of mannose binding to FimH have been described.
These pockets could potentially serve as targets for small molecule inhibitors.
Small molecule inhibitors of nucleolin may be more practical alternatives to oligonucleotides.
Targeting this protein with small molecule inhibitors is a promising anticancer strategy.
Small molecule inhibitors of HDACs and HATs are being investigated as cancer therapy.
There are several examples of small molecule inhibitors of protein kinase catalytic activity.
Small molecule inhibitors have also been used for induction of pancreatic endocrine precursor cells.
One of the most potent classes of small molecule inhibitors is from the fumagillin family.
A number of animal models exist to measure the potential hypertensive effects of small molecule inhibitors.
It is preferable that such small molecule inhibitors also possess advantageous bioavailability profiles.
See also
The receptor antagonists include antibodies and antibody fragments as well as intracellular small molecule inhibitors.
An overview of small molecule inhibitors of VEGFR signaling.
Often, oncogenic mutations of c-Met cause a resistance to small molecule inhibitors.
Small molecule inhibitors against RORYt have been reported in the literature for AI.
Artificial irreversible small molecule inhibitors include AEBSF and PMSF.
Small molecule inhibitors of MEK have been disclosed.
This assay was used to discover small molecule inhibitors of gamma-secretase.
Other small molecule inhibitors of Kit tyrosine kianse activity have also been identified.
The present invention provides novel small molecule inhibitors of cyclin-dependent kinases.
Small molecule inhibitors of B-Raf are being developed for anticancer therapy.
There has also been much progress in developing AKT-selective small molecule inhibitors.
Identification of small molecule inhibitors of Pseudomonas aeruginosa exoenzyme S using a yeast phenotypic screen.
Figure 5 is a graph illustrating the evaluation of small molecule inhibitors in the potency assay.
Small molecule inhibitors of n-terminus activation of the androgen receptor.
For this purpose, inhibition is accomplished using small molecule inhibitors or biological inhibitors.
Small molecule inhibitors as well as antibodies and antibody-derivatives can be used.
The present invention also provides small molecule inhibitors of HDAC6.
Thus, small molecule inhibitors of chymase are likely to represent useful therapeutic agents.
This change, when identified by screening, identifies small molecule inhibitors of MIF.
MethylGene has designed small molecule inhibitors that are selective for individual DNMT isoforms.
Other anti-inflammatory agents include NSAIDS, steroids and other small molecule inhibitors of inflammation.
Typical small molecule inhibitors include but are not limited to erlotinib, sorafenib or alisertib.
One approach has been to target the kinase activity of IGF-IR with small molecule inhibitors.
Several other small molecule inhibitors of angiogenesis-relevant targets are in clinical and preclinical development.
The crystal structures of complexes formed between SCD40L and small molecule inhibitors may be solved.
A variant for screening small molecule inhibitors of protein-protein interactions has also been described.
Other anti-inflammatory agents may further include NSAIDS, steroids, and other small molecule inhibitors of inflammation.
Small molecule inhibitors identified in this way would provide candidates for anti-inflammatory drugs.
The following references relate to small molecule inhibitors of GSK-3 and their applications.
Small molecule inhibitors of MDM2 and the uses thereof.
Ligands may include, but are not limited to, small molecule inhibitors.
Several small molecule inhibitors of PFKFB3 are currently in development.
Similar results were obtained with small molecule inhibitors of SirT1 and MetAP2.
Thus, small molecule inhibitors of cat G and HC are likely to represent useful therapeutic agents.
The term " pilicide ", as used herein, refers to small molecule inhibitors of filament biogenesis.
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