Examples of 'sonidegib' in a sentence
Meaning of "sonidegib"
sonidegib (noun): A pharmaceutical term for a medication used in the treatment of basal cell carcinoma
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- A particular anticancer drug.
How to use "sonidegib" in a sentence
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sonidegib
Sonidegib may pass into the semen.
It is unknown whether sonidegib is excreted in human milk.
Odomzo contains the active substance sonidegib.
Agents that may increase sonidegib plasma concentration.
Sonidegib was evaluated in rats and dogs.
Agents that may decrease sonidegib plasma concentration.
Sonidegib has not been studied in a dedicated pharmacokinetic study in patients with renal impairment.
It is unknown whether sonidegib is contained in semen.
Sonidegib binding to Smo will inhibit Hh signalling and consequently block signal transduction.
The active substance is sonidegib as phosphate.
Steady state was reached approximately 4 months after starting sonidegib.
Effects of sonidegib on other medicinal products.
There are no data on the use of sonidegib in pregnant women.
Co-administration of sonidegib with strong CYP3A inducers decreases sonidegib plasma concentration.
Active substance sonidegib.
See also
The bioavailability of sonidegib is increased in the presence of food see section 5.2.
The effect of renal impairment on the systemic exposure of sonidegib has not been studied.
Based on the available data, sonidegib elimination via the kidney is negligible.
CK levels should be measured weekly for 2 months after re-administration of sonidegib and monthly thereafter.
Steady-state level of sonidegib in the skin was 6-fold higher than in plasma.
All the metabolites were deemed 4 to 90 times less potent than sonidegib.
Months after re-administration of sonidegib and monthly thereafter.
Re-introduce sonidegib at 200 mg every other day and follow the same monitoring recommendations.
Each hard capsule contains 200 mg sonidegib as phosphate.
The elimination half-life ( t1/2 ) of sonidegib estimated from population pharmacokinetic modeling was approximately 28 days.
Sonidegib is a competitive inhibitor of CYP2B6 and CYP2C9 in vitro.
Sonidegib is primarily metabolised by CYP3A4.
