Examples of 'squalamine' in a sentence
Meaning of "squalamine"
squalamine (noun) - Squalamine is a compound that is found in certain species of dogfish sharks. It has been studied for its potential use in medical treatments, particularly for its antimicrobial and anticancer properties. Squalamine is also being investigated for its potential to treat neurodegenerative diseases
Show more definitions
- A broad-spectrum antibiotic derived from the livers of dogfish
How to use "squalamine" in a sentence
Basic
Advanced
squalamine
Methods for synthesizing squalamine have been described.
A preferred compound for such utilities is squalamine.
Squalamine has an especially potent activity.
Applicants have discovered still further uses of squalamine.
A squalamine toxicity test was performed in another animal model.
This result indicates that squalamine has little or no toxicity.
Squalamine could be detected in many tissues of the shark.
A second repeat dose of squalamine was added at the time of adding neutrophils.
Squalamine retained its antimicrobial activity after boiling.
Applicants have further observed that squalamine changes endothelial cell shape.
Squalamine did not induce inflammation at any of these concentrations.
An especially preferred and advantageous composition contains squalamine and an anionic lipid.
Squalamine has potent antiangiogenic activity and is a preferred compound for cancer therapy.
Pharmaceutically acceptable salts of squalamine may be prepared by methods well known in the art.
The present invention also provides pharmaceutical compositions which include squalamine as an active ingredient.
See also
It is expected that combined squalamine and cytotoxic chemical treatment will extend survival.
This suggests that transport proteins which control cell volume and shape may be a squalamine target.
Such compositions include a therapeutically effective amount of squalamine and a pharmaceutically acceptable carrier or excipient.
The activity of squalamine is shown in comparison with several other related molecules in Table I.
In effect, the growth factor signal is aborted in the presence of squalamine.
The results reflect that squalamine exerts this effect through inhibition of NHE.
Compounds having various ranges of activities were found, with squalamine being especially active.
In addition, squalamine is antifungal and exhibits lytic activity against protozoa.
The following examples are provided to illustrate the isolation, activity and biodistribution of squalamine.
In addition, squalamine has been determined to inhibit the exchanger through a special mechanism.
Thus, endothelial cells are more sensitive to squalamine than are either fibroblasts or epithelial cells.
Furthermore, squalamine exerts antibiotic activity at concentrations below which erythrocyte disruption is observed.
As a consequence, the sodium / proton exchanger is more profoundly inactivated by squalamine than by amiloride.
At these concentrations, squalamine does not appear to profoundly affect cell viability or proliferation.
Figure 2c is a proton NMR spectrum of squalamine.
Products according to claim 4, wherein squalamine is under a form adapted to subcutaneous administration.
Squalamine is undergoing trials for treatment of non-small cell lung cancer stage I/IIA.
Products according to claim 5, wherein squalamine is to be used after the cytotoxic chemical compound.
Squalamine was examined as adjunctive therapy following a single 200 mg / kg dose of cyclophosphamide.
From this, applicants conclude that squalamine probably does not cross the brain / blood barrier.
A use according to any one of claims 1 to 6, wherein said agent is squalamine.
More specifically, squalamine exhibits high antiangiogenic activity even after three weeks.
As demonstrated by the experiments described above, squalamine provides a potent inhibitor of NHE3.
Using this test, squalamine was found to be a potent inhibitor of tumor induced capillary formation.
The preferred method of preparing aminosterol compound squalamine is illustrated in Scheme 2 below,.
Example 1 - Isolation of Squalamine Squalus acanthias sharks were captured off of the New England coast.
Figure 8 shows the pharmacokinetic clearance of squalamine from a mouse IV PK study.
Through the application of these assays, compound 319 emerged as an attractive alternative to squalamine.
This indicates that squalamine inhibits human NHE3.
Compound 319 also has a more rapid pharmacokinetic clearance than squalamine.
Notably, however, not much squalamine is present in brain tissue.
Figure 2B shows the lack of inhibition of human NHE1 by squalamine.
Fig . 7 illustrates the distribution of squalamine in mouse tissue two hours after i . v. administration.
Squalamine has been found to specifically inhibit NHE3 and not NHE1 or NHE2.
The test results shown in Fig . 7 indicate good squalamine distribution.
