Examples of 'stromelysin' in a sentence
Meaning of "stromelysin"
stromelysin (noun) - a type of enzyme known as matrix metalloproteinase-3, involved in breaking down extracellular matrix proteins
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- Any of a family of metalloproteinases that cleave extracellular matrix proteins.
How to use "stromelysin" in a sentence
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stromelysin
Specifically assays are known for stromelysin and collagenase.
The stromelysin target was then exposed to a database of test compounds.
Some compounds only bound to stromelysin in the presence of hydroxamic acid.
Stromelysin activity can also be determined using human aggrecan as a substrate.
Endogenous fibrinolytic metalloproteinases include any of the stromelysin class of metalloproteinases.
Specific inhibitors of stromelysin and collagenase may be useful as birth control agents.
Many of the biaryl compounds were found to bind the catalytic domain of stromelysin.
The compound that exhibited the best inhibition of stromelysin contained a linker with two methylene units.
Studies were performed to design new ligands that bound to the catalytic domain of stromelysin.
Both collagenase and stromelysin activities are observed in fibroblasts isolated from inflamed gingiva J.
Various biaryl compounds of structure I were tested for binding to stromelysin at differing concentrations.
Because stromelysin undergoes autolysis, an inhibitor was sought to block the degradation of stromelysin.
Based on these initial hits, structurally similar compounds were tested against stromelysin.
Agents that inhibit over-expression of collagenase and stromelysin are potential antiarthritic agents.
Inhibition of stromelysin activity may prevent the rupturing of atherosclerotic plaques, leading to coronary thrombosis.
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They are classified into collagenases, gelatinases, and stromelysin according to the nature of their substrate.
Depending on the nature of their substrate, they are classified into collagenases, gelatinases and stromelysin.
The IC ₅ ₀ for inhibition of stromelysin activity is graphically derived and Ki is calculated.
These compounds have inhibitory activity against matrix metalloproteinases such as collagenase, stromelysin and gelatinase.
The catalytic domain of stromelysin was prepared in accordance with the procedures of Example 1.
The enzyme concentration was 13nM stromelysin.
The purified soluble fraction of the stromelysin fragment is concentrated and stored at 4°C.
Xenopus stromelysin 3 promoter containing several TREs ( cloning in the HindIII site ).
A composition according to claim 11, wherein said stromelysin is an endogenous stromelysin.
MMP-3 belongs to the stromelysin proteases and is capable of degrading both elastin and proteoglycans.
They are classified, depending on the nature of their substrate, as collagenases, gelatinases and stromelysin.
Use according to Claim 1, wherein said stromelysin is an endogenous stromelysin.
However, the production of only one proteolytic enzyme is mentioned, namely, the metalloprotease stromelysin.
Further, stromelysin and IL-1 diffuse into the cartilage matrix of the tibial plateau.
The purified soluble fraction of the isotopically-labeled stromelysin fragment was concentrated and stored at 4°C.
Activated stromelysin is diluted in assay buffer to 25 µg / ml.
And MMP is classed as collagenase, gelatinase, stromelysin and Membrane-type MMP.
Activated stromelysin is diluted in assay buffer to 25 mg / ml.
A diagnostic method according to claim 25, wherein said stromelysin is MMP-3.
Activated stromelysin is diluted in assay buffer to 25 ug / ml.
The Novel Compounds also inhibit collagenase and stromelysin at concentrations of from 0.3 to 10 nM.
To direct GLP-1 to the secretory pathway, the heterologous signal sequence of stromelysin 3 Acc . No.
There may also be a role for stromelysin activity during ovulation Too et al ( 1984 ) Endocrin.
Briefly, as shown in Figure 20, IL-1 induction increases collagenase and stromelysin mRNA levels in chondrocytes.
In this Figure, the apparent binding regions in stromelysin are shown for Compound 1 ( from Table 1 ).
FIG . 4, Assay for functionality of the construct “ xenopus stromelysin 3 promoter coupled to luciferase ”.
